【摘要】 目的:观察氢溴酸樟柳碱预防给药对急性脑缺血再灌注损伤大鼠的保护作用。方法:采用大鼠大脑中动脉栓塞法制备急性脑缺血再灌注损伤大鼠模型,观察预防给药对缺血再灌注大鼠行为学评分、脑梗死面积、脑含水量以及血清NO、NOS、Ach、AchE的影响。结果:与模型动物比较,氢溴酸樟柳碱在预防给药小剂量下对神经行为学评分有明显改善,在脑梗死面积、脑水肿、NOS、NO方面小剂量组也都表现出改善趋势,大剂量组在脑行为学方面、脑梗死面积、NOS及Ach方面表现出改善趋势。结论:氢溴酸樟柳碱预防给药对急性脑缺血再灌注损伤大鼠有一定的保护作用。更多还原

【Abstract】 Objective:To investigate the protective effect of Anisodine Hydrobromide on acute cerebral ischemia-reperfusion injury in rats. Method:The model of rat acute cerebral ischemia-reperfusion injury was established through middle cerebral artery occlusion-reperfusion. Anisodine Hydrobromide was injected before model establishment. The behavior,cerebral infarction size and water content of ischemic rats were evaluated,and the influence on NO,NOS,Ach and AchE in serum were measured. Result:The low dose of Anisodine Hydrobromide could significantly improve the behavior of ischemic rats and show a tendency of decreasing infarct size water content,NOS activity and NO content. Large dose showed the tendency in improving behavior,infarct size,NOS activity and Ach content. Conclusion:Anisodine Hydrobromide has protective effect against brain damage induced by occlusion–reperfusion in middle cerebral artery of rats.更多还原