【摘要】 目的探讨特异性核基质结合区蛋白-1(SATB1)和亲水性蛋白-1(KISS1)在胃腺癌组织中的表达及其临床意义。方法采用免疫组织化学法检测76例胃腺癌组织及19例癌旁正常胃黏膜组织中SATB1、KISS1的表达情况,并分析其表达与临床病理特征和预后的关系。结果 SATB1、KISS1在胃腺癌组织中的阳性表达率分别为80.3%(61/76)和14.5%(11/76),与正常胃黏膜组织的10.5%(2/19)、89.5%(17/19)比较,差异有统计学意义(P<0.01)。SATB1和KISS1的表达与胃癌淋巴结转移、远处转移、TNM分期有关(P<0.05),而与年龄、性别、肿瘤直径和组织分化程度无关(P>0.05);SATB1和KISS1的表达呈负相关(r=-0.736,P<0.01)。SATB1阳性和阴性表达患者的中位总生存时间(OS)分别为16.8个月(95%CI:10.124~21.876个月)、42.2个月(95%CI:31.804~52.196个月),差异有统计学意义(P<0.05);KISS1阳性和阴性表达患者的中位OS分别为45.1个月(95%CI:36.736~53.264个月)、13.6个月(95%CI:9.971~16.029个月),差异有统计学意义(P<0.05)。结论胃腺癌组织中SATB1、KISS1的表达与胃腺癌发生、发展及侵袭性有关,二者均可作为评价胃腺癌生物学行为的指标。更多还原

【Abstract】 Objective To examine the expressions of special AT-rich sequence binding protein-1( SATB1),kisspeptin-1( KISS1) in human gastric adenocarcinoma and investigate their relevance and clinical significance. Methods The expressions of SATB1 and KISS1 were detected in 76 gastric adenocarcinoma and 19 adjacent normal gastric tissues by tissue chip technology and immunohistochemical staining. The correlation of the expressions with clinicalpathological features and prognosis were analyzed. Results The positive rate of SATB1 and KISS1 in gastric adenocarcinoma tissues were 80. 3%( 61 /76) and 14. 5%( 11 /76) respectively. Compared with10. 5%( 2 /19) and 89. 5%( 17 /19) of normal gastric tissue,the differences were statistical significantly( P < 0. 05). The SATB1,KISS1 expressions were related to invasive depth,metastasis and TNM staging( P < 0. 05),but not related to age,sex,tumor diameter and histological differentiation( P > 0. 05). SATB1 was negatively correlated with KISS1( r =- 0. 736,P < 0. 01). The median overall survival( OS) of SATB1 positive and negative patients was 16. 8 months( 95% CI: 10. 124-21. 876 months) and 42. 2 months( 95% CI: 31. 804-52. 196 months),and the difference was statistically significant( P < 0. 05). The median OS of KISS1 positive and negative patients was45. 1 months( 95% CI: 36. 736-53. 264 months) and 13. 6 months( 95% CI: 9. 971-16. 029 months),and the difference was statistically significant( P < 0. 05). Conclusion SATB1 and KISS1 play important roles in carcinogenesis and progression of gastric adenocarcinoma,which can be regarded as useful biomarkers to evaluate the biological characteristics of gastric adenocarcinoma.更多还原