【摘要】 目的 探讨选择性5·羟色胺再摄取抑制剂治疗脑卒中后抑郁患者神经功能缺损状况的临床疗效。方法 在中、英文数据库内按照选定的关键词与主题词检索所有关于5·羟色胺再摄取抑制剂干预脑卒中后抑郁患者运动功能的临床随机对照试验,提取原始数据,对纳入文献进行质量评估,采用RevMan 5.2软件进行Meta.分析。结果 共纳入7篇临床随机对照试验研究,包括588例脑卒中后抑郁患者。Meta分析结果显示:治疗结束时干预组卒中量表减分率达有效水平的概率显著高于对照组,两组间有效率比较差异有极显著性[RR=1.59,95%CI(1.38,1.82),P<0.01];干预组运动功能缺损情况较对照组改善更显著,两组间治愈率比较差异有极显著性[RR=1.84,95%CI(1.43,2.36),P<0.01]。结论 5·羟色胺再摄取抑制剂类抗抑郁剂能有效改善脑卒中后抑郁患者的神经功能缺损状况,促进患者运动功能的恢复。更多还原

【Abstract】 Objective To explore the efficacy of selective serotonin reuptake inhibitors(SSRIs) on neurologic impairment of patients with post-stroke depression(PSD).Methods Randomized controlled trials(RCT) about motor function of PSD patients treated with SSRIs were retrieved according to selected keywords and subject terms from Chinese and English database,primary data extracted,quality of included literatures assessed,and meta-analyses carried out using RevMan 5.2 software.Results Seven literatures were brought into and 588 patients included.The meta-analyses showed that at the end of treatment the probability of the reducing score rate of the Stroke Scale reaching significant level was significantly higher in intervention than in control group,there was significant group difference in effective rate[RR=1.59,95%CI(1.38,1.82),P<0.01];motor function impairment improved more significantly in intervention than in control group,there was very significant group difference in recovery rate[RR=1.84,95%CI(1.43,2.36),P<0.01].Conclusion SSRIs could effectively improve neurologic impairment of PSD patients and promote patients’ motor function recovery.更多还原