【摘要】 帕金森病是中老年人群中最常见的神经系统退行性疾病之一,其主要病理特征是黑质致密部多巴胺能神经元的变性丢失,引起多巴胺分泌不足。胰岛素样生长因子-1能促进多巴胺能神经元的存活,且相关实验证实帕金森病患者血清胰岛素样生长因子-1水平发生了变化。文中对血清胰岛素样生长因子-1与帕金森病的关系作一综述。更多还原

【Abstract】 In the population older than 60 years, Parkinson’s disease(PD) is one of the most common neurodegenerative disorders, characterized by progressive loss of dopaminergic neurons(DN) in the substantia nigra pars compacta(SNpc), leading to inadequate secretion of dopaminergic(DA). Insulin-like growth factor 1(IGF-1) can promote the survival of DN, and the levels of serum IGF-1 in PD were changed in several related studies. The relationship between serum IGF-1 and PD were reviewed.更多还原