【摘要】 目的:探讨包头地区儿童特应性皮炎(AD)与肥胖的相关性,为儿童AD的治疗提供新的思路。方法:212例AD患儿,年龄0~9岁,对照组为随机选取的424例同期进行健康体检的同龄儿童。采用免疫印迹方法检测血清特异性Ig E抗体水平;测量身高及体重,评估年龄段体重指数百分度;采用湿疹面积及严重度指数(EASI)评分评估皮损严重程度;采用条件逻辑归因分析评估AD与肥胖的相关性。结果:经调整多种潜在性干扰因素后,肥胖与AD(OR=4.1,95%CI:2.23~5.76,P<0.01)及AD皮损严重程度(OR=2.15,95%CI:1.31~3.56,P<0.01)均密切相关。结论:儿童AD的发生发展与肥胖密切相关;肥胖是儿童AD皮损加重的危险因素之一。更多还原

【Abstract】 Objective: To investigate the association between obesity and atopic dermatitis(AD) in children in Baotou area in order to develop new ideas for treating AD children.Methods: 212 children with AD aged 0 to 9 years and 424 agematched healthy controls were enrolled from January 2010 to June 2014 in the hospital.Allergen specific Ig E levels were measured using immunoblotting.The height,weight and body mass index-for-age of percentiles were assessed.The extent of lesion severity was evaluated using eczema area and severity index(EASI).The association between obesity and AD was assessed using a conditional logistic regression method.Results: After adjustment for multiple potential confounding factors,obesity was significantly associated with AD(OR=4.1,95%CI:2.23~5.76,P<0.01) and the severity of AD(OR=2.15,95%CI:1.31~3.56,P<0.01).Conclusions: The development and progression of AD in children are closely associated with obesity.Obesity is a risk factor for exacerbation of AD in children.更多还原