【摘要】 目的:观察沙利度胺对复发性阿弗他溃疡(RAU)患者外周血淋巴细胞亚群的影响及治疗疗效。方法:选择轻型RAU患者(轻型RAU组)85例,健康对照组80例,随访观察服用沙利度胺25 mg/d治疗轻型RAU的疗效;同时比较健康对照组,轻型RAU组治疗前后外周血淋巴细胞亚群检测结果。结果:和健康对照组相比,轻型RAU患者CD4+T淋巴细胞数目减少,CD8+T淋巴细胞增多,淋巴细胞亚群比例失调;经沙利度胺治疗后,轻型RAU患者淋巴细胞亚群比例异常改善,同时患者溃疡间歇期明显延长,溃疡数目明显减少,差异均具有统计学意义(P<0.05)。结论:轻型RAU患者存在外周血T淋巴细胞亚群比例异常,沙利度胺可有效调节CD4~+、CD8~+T淋巴细胞亚群比例,延长溃疡间歇期,减少溃疡发作,临床疗效满意。更多还原

【Abstract】 Objective: To observe the clinical efficacy of Thalidomide in the treatment of Recurrent Aphthous Ulcers( RAU) and its impact on subsets of lymphocytes in the peripheral circulation. Methods: Thalidomide was administered to 85 patients with RAU minor at 25 mg per day. The clinical effect was measured by comparing the remission time and the number of ulcers pre-and post-intervention. Meanwhile,the total number of peripheral lymphocytes and the ratio of CD4+T cell to CD8+T cells were measured before and after the intervention compared with the control group consisted of health participants. Results: Compared to the control group,there was a significant decrease of CD4+T cells and increase of CD8+T cells( P < 0. 05) in the patients with RAU minor before the treatment. The ratio of the two subsets was also abnormal. After the intervention,the ratio of the lymphocyte subsets was improved. Meanwhile,there was a significant increase in the remission time of the ulcers and reduced in the number of ulcers in patient group( P < 0. 05). Conclusion: The ratio of the peripheral lymphocyte subsets is abnormal in patients with RAU. Thalidomide has a significant effect in correcting the abnormal ratio of CD4+T cells to CD8+T cells. It can also increase the remission time of ulcers and reduce the frequency of ulcer breakouts.The clinical efficacy has been satisfactory.更多还原