【摘要】 目的:比较氨磺必利及利培酮对首次发病的精神分裂症患者疗效及糖脂代谢的影响。方法:采用随机双盲法将86例首发精神分裂症患者分为研究组和对照组,每组43例;分别给予氨磺必利和利培酮治疗8周。治疗前后进行阳性和阴性症状量表(PANSS)和治疗中出现的症状量表(TESS)评分;测量体质量指数(BMI)、空腹血糖(FPG)、口服糖耐量实验2 h血糖(2h PG)、血清胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、高密度脂蛋白(HDL)、三酰甘油(TG)、总胆固醇(TC)。结果:治疗后两组PANSS评分明显下降(P均<0.05),两组间PANSS评分及临床总有效率差异无统计学意义;研究组不良反应发生率(25.6%)明显低于对照组(62.8%)(P<0.05);研究组治疗前后糖脂代谢指标(BMI、FPG、2h PG、FINS、HOMA-IR、HDL、TG和TC)比较差异无统计学意义;对照组BMI、FPG、2h PG、FINS、HOMA-IR、TG和TC水平较治疗前及研究组明显增高(P<0.05或P<0.001)。结论:氨磺必利对首发精神分裂症患者的疗效与利培酮相似,不良反应少,短期治疗不影响患者的糖脂代谢。更多还原

【Abstract】 Objective: To compare the effect and influence on glucose and lipid metabolism of amisulpride and risperidone in first-episode schizophrenic patients. Method: Eighty-six first-episode schizophrenic patients were randomly divided into study group and control group,43 cases in each group. The patients in those groups were treated with amisulpride or risperidone respectively for 8 weeks. Before and after treatment,the patients of the two groups were assessed by positive and negative symptoms scale( PANSS),treatment emergent symptoms scale( TESS); and their body mass index( BMI),fasting plasma glucose( FPG),2-hour postprandial blood glucose( 2h PG),fasting insulin( FINS),Homeostasis model assessment for insulin resistance( HOMA-IR),high density lipoprotein( HDL),triglyceride( TG),total cholesterol( TC) were detected respectively.Results: After treatment the scores of PANSS were decreased significantly in both groups. The score of PANSS and clinical efficacy between the two groups had no significant difference. The incidence of adverse reactions in the study group( 25. 6%) was significantly lower than the control group( P < 0. 05). Glucolipid metabolism indexes including BMI,FPG,2h PG,FINS,HOMA-IR,HDL,TG and TC in the study group showed no significant difference between before and after treatment. But the indexes of BMI,FPG,2h PG,FINS,HOMA-IR,TG and TC after treatment in the control group were significantly increased than before treatment and the study group( P <0. 05 or P < 0. 001). Conclusion: The efficiency of amisulpride in first episode schizophrenic patients is similar to risperidone; and its adverse reaction is less than risperidone; short-term treatment does not affect the glucolipid metabolism of patients.更多还原