【摘要】 目的通过检测血清脂联素(APN)、铁蛋白(SF)水平在青海地区非酒精性单纯性脂肪肝(NAFL)患者及正常人群中的变化,探讨APN、SF在NAFL发病中的意义。方法选取2015年2-10月在青海大学附属医院确诊为NAFL的39例患者作为病例组(NAFL组),34例健康体检者作为对照组,测定其人体学指标及临床常规生化指标,采用ELISA和化学发光免疫分析法分别检测血清APN、SF水平。2组间比较采用成组t检验,相关性分析采用Pearson相关分析法。结果 NAFL组SF水平明显高于正常对照组[(291.97±38.82)ng/ml vs(93.21±8.74)ng/ml,t=31.085,P<0.001];而血清APN水平显著低于正常对照组[(11.91±2.88)mg/L vs(16.18±2.80)mg/L,t=6.383,P<0.001]。相关性分析提示,NAFL组血清APN水平与TG呈负相关(r=-0.466,P<0.01)。结论青海地区NAFL患者血清APN降低,SF升高,NAFL组血清APN与TG呈负相关,APN水平受TG影响,监测血清APN水平可作为高甘油三脂血症治疗前后效果评价的参考指标。更多还原

【Abstract】 Objective To investigate the changes in the levels of serum adiponectin( APN) and serum ferritin( SF) in patients with nonalcoholic fatty liver( NAFL) and normal populations in Qinghai,China,as well as the significance of APN and SF in the pathogenesis of NAFL. Methods A total of 39 patients diagnosed with NAFL in The Affiliated Hospital of Qinghai University from February to October,2015 were enrolled as NAFL group,and 34 healthy individuals who underwent physical examination were enrolled as control group. The anthropometric parameters and routine clinical biochemical parameters were measured and enzyme-linked immunosorbent assay and chemiluminescence immunoassay were used to measure the levels of serum APN and SF. The independent-samples t test was used for comparison between two groups,and the Pearson correlation analysis was also performed. Results Compared with the control group,the NAFL group had a significantly higher level of SF( 291. 97 ± 38. 82 ng / ml vs 93. 21 ± 8. 74 ng / ml,t = 31. 085,P < 0. 001) and a significantly lower serum level of APN( 11. 91 ± 2. 88 mg / L vs 16. 18 ± 2. 80 mg / L,t = 6. 383,P < 0. 001). The correlation analysis showed that in the NAFL group,serum APN level was negatively correlated with TG level( r =-0. 466,P < 0. 01). Conclusion The patients with NAFL in Qinghai have a reduced serum APN level and an increased SF level,and in these patients,serum APN level is negatively correlated with TG level. Serum APN monitoring may be used as a reference index to evaluate the treatment outcome of hypertriglyceridemia.更多还原