【摘要】 目的应用Meta分析方法评价Fibro Scan所测肝脏硬度值(LS)诊断原发性肝癌的准确性。方法计算机检索Pub Med、Embase、中国生物医学文献数据库、中国生物医学期刊引文数据库、维普中文科技期刊数据库、中国知网,并人工检索相关期刊,全面收集2003年1月-2015年6月关于Fibro Scan所测LS诊断原发性肝癌的文献,采用QUADAS对文献质量进行评价和资料提取,用Meta Disc1.4软件对结果进行Meta分析。结果共纳入符合标准的6篇英文文献。异质性检验提示不存在阈值效应,但存在其他原因导致的异质性。纳入文献中LS诊断原发性肝癌的诊断界值为11~53.7 k Pa,LS诊断原发性肝癌的合并灵敏度、特异度、阳性似然比、阴性似然比、95%可信区间及其诊断比值比分别为0.66(0.61~0.71)、0.78(0.76~0.79)、3.19(2.39~4.25)、0.45(0.30~0.66)、8.63(4.34~17.18),综合受试者工作特征曲线下面积为0.8268,Q指数为0.7597。结论 Fibro Scan所测LS诊断肝癌的准确性良好,具有广泛的应用价值和推广前景。更多还原

【Abstract】 Objective To investigate the accuracy of liver stiffness( LS) measured by Fibro Scan in the diagnosis of primary liver cancer through a meta- analysis. Methods The databases of Pub Med,Embase,CBM,CMCI,VIP,and CNKI were searched,and a manual search was performed for related journals,to collect the articles on LS measured by Fibro Scan in the diagnosis of primary liver cancer published from January 2003 to June 2015. QUADAS was applied for quality evaluation and data extraction,and Meta Disc 1. 4 software was applied for the Meta- analysis. Results A total of 6 English articles which met the inclusion criteria were included. The tests for heterogeneity showed no threshold effect,but the presence of heterogeneity caused by other reasons. In the articles included,the cut- off value for LS in the diagnosis of primary liver cancer was 11- 53. 7 k Pa,and the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio,with their respective 95% confidence intervals,were 0. 66( 0. 61- 0. 71),0. 78( 0. 76- 0. 79),3. 19( 2. 39- 4. 25),0. 45( 0. 30- 0. 66),and 8. 63( 4. 34- 17. 18),respectively. The area under the summary receiver operating characteristic curve was 0. 8268,and the Q index was 0. 7597. Conclusion LS measured by Fibro Scan has good accuracy in the diagnosis of primary liver cancer,and holds promise for clinical application.更多还原