【摘要】 目的探讨免疫调节剂(母牛分枝杆菌菌苗)对肺结核合并2型糖尿病T细胞亚群及痰菌阴转率的影响。方法初治菌阳肺结核合并2型糖尿病200例,均给予抗结核及降血糖治疗,观察组108例加用母牛分枝杆菌菌苗,对照组92例未使用免疫调节剂,观察两组患者治疗前及治疗2个月末T细胞亚群变化及痰菌转阴率。结果治疗2个月末观察组和对照组的T细胞亚群及痰菌转阴率比较无统计学差异(P>0.05)。结论免疫调节剂(母牛分枝杆菌菌苗)对肺结核合并2型糖尿病的T细胞亚群及痰菌阴转无影响。更多还原

【Abstract】 Objective To investigate the effect of immune modulators on T cell subsets and sputum conversion in tuberculosis patients complicated with type Ⅱ diabetes. Methods 200 initial-treated smear positive pulmonary tuberculosis patients complicated with type Ⅱ diabetes were given anti-TB and hypoglycemic treatment. 108 cases in the observation group were treated with immunomodulatory agents( mycobacterium vaccae),while 92 cases in the control group weren’t given immunomodulatory agents. The changes of T cell subsets and sputum negative conversion were observed before and two months after the treatment. Results There was no significant difference in T cell subsets and sputum negative conversion between the two groups( P > 0. 05). Conclusion The immune modulators( mycobacterium vaccae) have no effect on T cell subsets and sputum negative conversion in tuberculosis patients complicated with type Ⅱ diabetes.更多还原