【摘要】 目的比较慢性阻塞性肺疾病（COPD）患者和健康受试者非侵入性标记物,评估其与吸烟的关系。方法选取在我院治疗的稳定期COPD戒烟患者52例（COPD EX组）,稳定期COPD吸烟患者36例（COPD S组）,在我院体检的健康的吸烟者23例（HE S组）,健康的戒烟者23例（HE EX组）。比较所有受试者呼出气冷凝物（EBC）、痰液中前列腺素E2（PGE₂）和异构前列腺素15-F2t-isoprostane（15-F2t-IsoP）的水平、呼出气一氧化氮（FeNO）、痰细胞计数和肺功能。结果与COPD S组比较,COPD EX组的FeNO值明显提高;与两健康组比较,两COPD组EBC中15-F2t-IsoP水平明显升高（P<0.05）;与同等健康状况的戒烟者比较,吸烟者尿液中15-F2t-IsoP水平升高（P<0.05）。结论不同类型炎症性标志物的联合检测分析可用于对COPD患者呼吸炎症的综合评估。更多还原

【Abstract】 Objective To compare the non-invasive markers between chronic obstructive pulmonary disease(COPD)patients and healthy subjects and to assess their relationship with smoking.Methods The subjects included52 COPD ex-smoking patients(COPD EX group,n =52)and 36 smoking patients(COPD S group,n =36)treated in our hospital,23 healthy ex-smokers(HE EX group,n =23)and 23 healthy smokers(HE S group,n =23)medically examined in our hospital.Prostaglandin E2(PGE2),and prostaglandin isomers 15-F2t-isoprostane(15-F2t-IsoP)concentrations in sputum,exhaled breath condensate(EBC),fraction of exhaled nitric oxide,sputum cell counts and pulmonary function test were detected and compared.Results Compared with COPD S group,FeNO values in COPD EX group increased significantly(P <0.01);Compared with healthy group,the EBC 15-F2t-IsoP concentrations in two groups with COPD increased significantly(P <0.05);Compared with smokers who had equal health status,the urine 15-F2t-IsoP concentration in both smokers groups increased significantly(P < 0.05).Conclusion The combination of different types of inflammatory markers can be used for a comprehensive assessment of COPD respiratory inflammation.更多还原