【摘要】 目的探讨新生儿脐动脉血血清淀粉样蛋白A(SAA),白细胞介素6(IL-6)水平变化及效能。方法收集2015年5月至2016年4月我院产科新分娩86例断脐后立即取脐动脉血3ml(极危重组13例、危重组23例、非危重组20例、正常组30例),应用酶联免疫吸附剂测定(ELISA)法进行血清SAA,IL-6水平测定,比较4组血清SAA,IL-6水平变化;采用受试者工作特性曲线(ROC)确定SAA,IL-6诊断新生儿危重症的适宜切点位,计算其判断新生儿危重症的敏感度、特异度。结果病例组中血清SAA、IL-6水平均高于正常组的新生儿,差异均有统计学意义(P均<0.05);SAA、IL-6表达水平均与危重症程度成正相关(P均<0.05)。SAA,IL-6诊断新生儿危重症ROC曲线下面积分别为0.925(95%CI=0.867~0.983,P<0.01),0.945(95%CI=0.902~0.988,P<0.01),SAA,IL-6敏感度,特异度各自依次分别为83.9%,96.7%,76.8%,96.7%。结论 SAA、IL-6能反映出患儿病情严重程度,较好的及时识别危重症新生儿。同时,SAA、IL-6也具有较高的敏感度,特异度,可在新生儿危重症的病情评估中应用。更多还原

【Abstract】 Objective To explore the change of newborn umbilical arterial blood serum amyloid A(SAA)and interleukin-6(IL-6).Methods A total of 86 cases of newborn umbilical arterial blood were collected between April2015 and March 2016,including 13 cases of extremely critical group,23 cases of critical group,20 cases of non-critical group and 30 cases of normal group.The levels of serum SAA and IL-6were determined by ELISA and compared between four groups.The receiver-operating characteristic curve(ROC)was adopted to define SAA and IL-6in the diagnosis of the critical point of tangency of a newborn.The judgement of sensitivity and specificity were calculated in the critically ill newborns.Results The levels of serum SAA and IL-6in disease groups were significantly higher than those in normal group(P <0.05).The levels of SAA and IL-6were positively correlated with the degree of critically illness(P <0.05).The areas of SAA and IL-6in the diagnosis of neonatal critical illness under ROC curve were 0.925(95%CI)and 0.945(95%CI),respectively.The sensitivity and specificity of SAA were 83.9% and 96.7%,respectively;the sensitivity and specificity of IL-6 76.8% and 96.7%,respectively.Conclusion The levels of SAA and IL-6can reflect the severity of illness and better identify the critical neonates in a timely manner.Meanwhile,the SAA and IL-6have higher sensitivity and specificity and can be used in neonatal critical illness assessment.更多还原