This paper takes the background of cobalt oxalate synthesis in cobalt hydrometallurgy process, and an adaptation optimization strategy for mean particle size of cobalt oxalate based on multi-way partial least squares(MPLS) model is studied. Firstly, the MPLS algorithm is used to build the data model of mean particle size of cobalt oxalate. In order to overcome the problem that it is difficult to obtain the optimal manipulated variables under model uncertainty, a modifier-adaptation strategy based batch-to-b...