【摘要】 〔目的〕建立阿托伐他汀钙分散片溶出度的测定方法。〔方法〕筛选介质(蒸馏水,p H1.2盐酸溶液,p H6.8磷酸盐缓冲溶液,p H7.4磷酸盐缓冲溶液);比较桨法和转篮法、紫外分光光度法测定。〔结果〕桨法,以水为介质,转速50 r/min为最佳测定方法。〔结论〕该法可用于阿托伐他汀钙分散片溶出度的测定。更多还原

【Abstract】 〔Objective〕Establishment of method for dissolution test of atorvastatin calcium dispersible tablets. 〔Methods〕Screed out dissolution media( water, p H 1. 2, Ph 6. 8, p H 7. 4 buffer); Contrasted paddle and basket method and then assayed by ultraviolet. 〔Results〕Paddle method( water, 50 r / min) was optimum. 〔Conclusion〕This method could be used for dissolution test of atorvastatin calcium dispersible tablets.更多还原