【摘要】 目的探讨血浆脑钠肽(BNP)检测在烧伤患者病情评估中的应用价值,为正确评价烧伤患者的病情提供更好的依据。方法选取梅州市人民医院2014年1月至2015年3月收治的烧伤患者68例进行研究,按照烧伤总体表面积不同分为3组,A组22例,烧伤面积小于或等于10%;B组27例,烧伤面积大于10%但小于或等于30%;C组19例,烧伤面积大于30%但小于或等于50%。另选取同期健康的受试者30例作为健康对照组。采用化学发光免疫分析法检测患者烧伤后第1、3、5、7天的血浆BNP水平,并对相关数据进行分析。结果烧伤后第1天各组血浆BNP水平均在正常值范围,与健康对照组相比,差异无统计学意义(P>0.05),从第3天开始,A、B、C 3组血浆BNP水平迅速升高,与健康对照组相比,差异均有统计学意义(P<0.05);且随着烧伤面积增大,各组各时间点比较差异均有统计学意义(P<0.05);血浆BNP水平峰值在烧伤后第3天或第5天;烧伤严重程度分级越高,血浆BNP水平升高幅度越大,严重烧伤患者在伤后第7天血浆BNP水平亦未恢复正常。经相关性分析发现,随着烧伤程度加重,其血浆BNP水平上升,呈正相关关系(r=3.117,P<0.05)。结论烧伤患者血浆BNP水平升高具有滞后性,与体表烧伤面积、病情变化及烧伤愈合程度等多种因素有关,在病情分级的基础上早期联合检测烧伤患者血浆BNP水平变化,对判断烧伤病情的严重程度、协助指导治疗、评估预后有一定的帮助。更多还原

【Abstract】 Objective To investigate the value of plasma BNP test condition assessment in burn patients,in order to provide a better basis for the correct evaluation of the patient′s condition.Methods Totally 68 burn patients from January 2014 to March 2015 in our hospital were selected.In accordance with the total body surface area burns,the patients were divided into three groups:group A(22 cases)with burns areas≤10%,group B(27cases)with burn area of>10%-30%,group C(19cases)with burn area>30%-50%,while 30 healthy subjects in the same period were enrolled as healthy control group.The plasma BNP levels on1 th,3th,5th,7th d after burn were detected by chemiluminescence immunoassay,and the data were analyzed.Results On the 1th d after burn,the plasma BNP levels was in the normal range,compared with the healthy control group,there was no statistically significant difference(P>0.05),on the 3th d,the plasma BNP levels in group A,B,C increased rapidly,compared with healthy control group,the difference had statistical significance(P<0.05);and with the increased of the burn area,the plasma BNP levels among groups and each time point were statistically significant(P<0.05);the peak of plasma BNP levels was on the 3th d or the 5th d after burn;the higher the grade the severity of the burn,the greater the magnitude of elevated plasma BNP levels,plasma BNP levels were not recovered to normal in 7th d after injury.And the correlation analysis showed that with the increase of the degree of burn,the level of plasma BNP was increased,and with positive correlation(r=3.117,P<0.05).Conclusion Plasma BNP level of burn patients with a lag,and is related to body surface area burn,the condition changes and burn healing degree et al.On the basis of disease classification,early joint monitoring plasma BNP level change of burn patients,helps to judge the severity of the disease,to assist in guiding the treatment and to evaluate the prognosis.更多还原