【摘要】 目的研究7种血清肿瘤标志物对原发性卵巢癌患者的临床诊断效果。方法选取该院接受治疗的原发性卵巢癌患者、良性卵巢肿瘤患者、同期体检健康女性,各75例,分析7种血清肿瘤标志物对原发性卵巢癌患者的诊断效果。结果与良性卵巢肿瘤组和健康对照组比较,卵巢癌组患者血清人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原153(CA153)、甲胎蛋白(AFP)、人绒毛膜促性腺激素(β-hCG)等水平显著升高,差异有统计学意义(P<0.05);与健康对照组比较,良性卵巢肿瘤组患者血清HE4、CA125、CEA、CA199、CA153等水平也显著升高,差异有统计学意义(P<0.05)。血清HE4、CA125、CEA的敏感性与准确性最高;血清CA153、AFP、β-hCG的敏感性与准确性最低。血清HE4、CA125、CEA 3项指标联合检测的敏感性、特异性与准确性最高;血清HE4与CEA 2种指标联合检测的敏感性、特异性与准确性最低。结论联合检测原发性卵巢癌患者血清HE4、CA125、CEA肿瘤标志物,其敏感性、特异性、准确性最高,具有临床诊断价值。更多还原

【Abstract】 Objective To study the diagnostic effect of seven kinds of serum tumor markers for patients with primary ovarian cancer.Methods 75 cases of primary ovarian cancer,75 cases of benign ovarian tumor patients and the same number of healthy females in our hospital were selected to accept the treatment,morever,seven kinds of serum tumor markers was analysed in ovarian cancer patients with the diagnosis of primary.Results Compared with the benign ovarian tumor group and the healthy control group,the levels of serum HE4,CA125,CEA,CA199,CA153,AFP,β-hCG tumor mark in the patients with ovarian cancer increased significantly(P<0.05);compared with the healthy control group,the levels of serum HE4,CA125,CEA,CA199,CA153 tumor markers significantly increased in the benign ovarian tumor patients(P<0.05).The sensitivity and accuracy of serum HE4,CA125,CEA were the highest;the sensitivity and accuracy of serum CA153,AFP,β-hCG were the lowest.The combined detection of sensitivity,specificity and accuracy of serum HE4,CA125,CEA were the highest;the combined detection of sensitivity,specificity and accuracy of serum HE4 and CEA were lowest.Conclusion For the patients with primary ovarian cancer,the combined detection of sensitivity,specificity and accuracy of the three serum HE4,CA125,CEA tumor mark is the highest.更多还原