【摘要】 目的探究连续性肾脏替代治疗(CRRT)对重症感染引起急性肾损伤患者血清炎性介质的影响。方法选取我院收治的重症感染引起急性肾损伤患者60例,随机分为两组,每组30例患者。所有患者均实施常规治疗,观察组联用CRRT治疗。比较两组患者血清炎性介质水平。结果治疗前,两组患者血清炎性介质水平对比,差异无统计学意义(P>0.05);治疗后,观察组患者的TNF-α水平高于对照组,而IL-4、IL-6、IL-10水平低于对照组,差异具有统计学意义(P<0.05)。结论采用CRRT对治疗重症感染引起急性肾损伤有良好的临床效果,可有效改善患者体内血清炎性介质水平。更多还原

【Abstract】 Objective To investigate the effect of continuous renal replacement therapy(CRRT) on the serum inflammatory mediators of acute kidney injury(AKI) patients caused by severe infection. Methods 60 AKI patients caused by severe infection treated in our hospital were randomly divided into two groups, 30 cases in each. All the patients took conventional treatment and observation group took CRRT additionally. The serum inflammatory mediators of two groups were compared. Results There was no statistical significance in the level of serum inflammatory mediators before treatment(P>0.05); After treatment, the TNF-α level of observation group was significantly higher than control group, while IL-4, IL-6, IL-10 levels were significantly lower than control group(P<0.05). Conclusion CRRT for treating AKI caused by severe infection has good clinical effects and it can effectively improve the level of serum inflammatory mediators for patients.更多还原