【摘要】 目的探讨冠心病、高血压及冠心病合并高血压与Hcy相关性。方法回顾性分析我院2014年1月~2016年3入院且完善Hcy检测的患者,根据其诊断将患者分为四组:冠心病组、高血压组、冠心病合并高血压组及无高血压冠心病组,通过对四组患者Hcy水平的比较,探讨冠心病、高血压及冠心病合并高血压与Hcy的相关性。结果高血压组Hcy水平较无高血压冠心病组明显升高(P<0.01),3级高血压患者Hcy水平明显高于2级高血压,2级高血压患者Hcy水平明显高于1级高血压;当Hcy>10μmol/L时,随着Hcy水平升高,心血管事件发生率呈增高趋势;冠心病组Hcy水平较无高血压冠心病组明显升高(P<0.01),冠心病分型与Hcy水平不完全一致;冠心病合并高血压组Hcy水平较无高血压冠心病组明显升高(P<0.01)。结论血清Hcy水平与高血压、冠心病、冠心病合并高血压的发生存在相关性,Hcy水平的测定对高血压、冠心病的发生有预测作用。更多还原

【Abstract】 Objective To discuss the correlation between coronary heart disease, hypertension, coronary heart disease with hypertension and homocysteine(Hcy). Methods We conducted a retrospective analysis on the patients form January 2014 to March 2016 in our hospital whose homocysteine were detected. At the same time, the patients were divided into four groups according to their diagnosis, coronary heart disease group, hypertension group, coronary heart disease with hypertension group and non-hypertension or coronary heart disease group. The correlation between coronary heart disease, hypertension, coronary heart disease with hypertension and homocysteine were discussed by comparing the levels of homocysteine in the four groups. Results The Hcy of hypertensive patients were higher than the patients with non-hypertension or coronary heart disease(P<0.01). The Hcy of grade 3 hypertensive patients were higher than the grade 2 hypertensive patients(P<0.01). The Hcy of grade 2 hypertensive patients were higher than the grade 1 hypertensive patients(P<0.01). When Hcy was more than 10μmol/L, with elevated Hcy levels, the incidence of cardiovascular events tended to increase with Hcy elevating. The Hcy of coronary heart disease patients were higher than the patients withnon-hypertension or coronary heart disease(P<0.01), but not all the subtype of coronary heart disease have correlation with Hcy. And the Hcyofcoronary heart disease with hypertension was higher than the patients with non-hypertension or coronary heart disease. Conclusion There is correlation between coronary heart disease, hypertension, coronary heart disease with hypertension and Hcy. The determination of Hcy level was good to the treatment and prognosis of coronary heart disease, hypertension.更多还原