【摘要】 目的探讨MRI引导下射频消融(RFA)治疗较大血管旁兔肝VX2肿瘤的疗效。方法选取11只新西兰大白兔,在MRI引导下将VX2肿瘤种植在兔肝大血管(直径≥3mm)旁。2~3周后行MR扫描,随机处死1只实验兔,行病理证实。剩余10只肿瘤兔行MRI引导下RFA,术后MR扫描后即刻处死实验兔行病理学检查。结果 11只实验兔肝脏VX2肿瘤均种植成功,肿瘤平均直径(1.35±0.22)cm。3D-vibe上肿瘤呈稍低信号,FS-TSE T2WI上呈稍高信号。10只肿瘤兔均成功接受RFA,消融灶在T2WI上呈等低信号;3D-vibe上呈同心圆状改变;大体病理上RFA凝固坏死区最大径为(2.16±0.50)cm,3D-vibe上高信号消融灶最大径为(2.27±0.66)cm,FS-TSE T2WI上低信号消融灶最大径为(2.25±0.58)cm,三者比较差异均无统计学意义。血管旁部分不完全消融的2个病灶,在3D-vibe显示为高信号环未完全包绕低信号瘤灶。结论 MRI引导下RFA治疗兔肝VX2肿瘤是一种有效、可行的治疗方法。更多还原

【Abstract】 Objective To explore the curative effect of MRI-guided radiofrequency ablation（RFA）in treatment of VX2 tumor adjacent to major blood vessels in rabbit liver.Methods Under the guidance of MRI,the VX2 tumor was implanted near the large blood vessel（diameter≥3mm）in 11 New Zealand rabbits liver.MRI was performed 2—3weeks after the implantation and 1rabbit was executed radomly for pathological confirmation.The remaining 10 rabbits received MRIguided RFA.The rabbits were sacrificed immediately after post-operative MR scan and pathological examination was carried out.Results All of the VX2 liver tumor of rabbits were established successfully,the average diameter of tumors was（1.35±0.22）cm.The VX2 tumor demonstrated slightly hypointensity on 3D-vibe and hyperintensity on T2 WI.All of the VX2 liver tumor of 10 rabbits were underwent RFA successfully.The ablated lesion showed a low-intensity signal on T2 WI and a concentric pattern on 3D-vibe.The mean maximal diameter of coagulated zone（D_R）was（2.16±0.50）cm on gross pathology,the mean maximal diameter of high signal ablated zone(D_T1)was（2.27±0.66）cm on the images of 3D-vibe,the mean maximal diameter of low signal ablated zone(D_T2)was（2.25±0.58）cm on the image of FS-TSE T2 WI,there were no statistically significant among D_R,D_T1 and D_T2.The part of lesions beside the vascular in 2lesions were ablated incompletely,a high signal ring of ablation lesions was not completely around the low signal tumor lesions on 3D-vibe.Conclusion The MRI-guided RFA in treatment of VX2 tumor in rabbit liver is an effective and feasible technology.更多还原