【摘要】 目的通过动物实验探讨新型可降解食管支架的安全性和降解性能。方法用模具以医用聚对二氧环己酮(PPDO)编制成新型分段的可降解食管支架。选择实验用巴马猪9头,植入新型可降解食管支架。术后每周1次胃镜检查,直至支架降解滑落。胃镜下观察支架降解情况、周围黏膜增生情况及可能的并发症。结果术后第3周支架颜色渐由蓝色变成灰白色,支架丝材变细,支架网眼增大明显;第7周支架丝材发生断裂现象;第8周支架完全降解滑落。支架植入后食管组织开始增生,3周时增生达顶点,4~7周时增生渐减轻,8周时食管黏膜恢复正常。结论新型PPDO可降解食管支架是安全的,均未发生严重并发症,支架所致食管组织增生反应可恢复,有一定的临床应用前景。更多还原

【Abstract】 Objective To investigate the safety and degradation property of a novel biodegradable esophageal stent by using animal experiment. Methods Using mold and medical polydioxanone(PPDO) a novel segmented and biodegradable esophageal stent was manufactured. Nine experimental Bama domestic pigs were selected, and the novel biodegradable esophageal stent was implanted into the pig ’s esophageal lumen. After stent implantation, gastric endoscopic examination was performed weekly until the stent was completely degraded and fell off. The stent degradation, the hyperplasia of surrounding mucosa and the possible complications were evaluated with gastric endoscopy examination. Results Three weeks after the operation, the color of the stent changed gradually from blue to grey white, the polydioxanone fibers became thin and fine, and the stent mesh was obviously enlarged. Seven weeks after the operation, fracture of polydioxanone fibers was seen. Eight weeks after the operation, complete degradation and falling-off of the stent was observed. After stent implantation the esophageal tissue began to proliferate, which reached its peak at 3weeks and then the proliferation was gradually weakened in 4-7 weeks, and the esophageal mucosa returned to normal in 8 weeks. Conclusion The use of novel PPDO biodegradable esophageal stent is quite safe, no serious complications have been observed. The esophageal tissue hyperplasia reaction induced by the stent is self-recovery. Therefore, this novel biodegradable esophageal stent has certain prospect of clinical application.更多还原