【摘要】 目的:观察中等强度跑台运动对去卵巢大鼠股骨头骨松质结构的影响,探讨运动对绝经期妇女骨质疏松的预防作用。方法:SD大鼠随机分为假手术组、去卵巢手术组、雌激素对照组和运动组。假手术组进行模拟手术不切除卵巢,其余各组行双侧卵巢切除术。手术2周后开始为期8周的干预治疗。雌激素对照组用尼尔雌醇治疗,运动组按要求进行运动。治疗结束后取股骨头骨松质进行树脂包埋及体视显微观察并进行骨组织形态计量学分析。结果:运动组的骨小梁面积、骨小梁厚度、骨小梁数量明显高于去卵巢手术组,骨小梁分离度、骨小梁游离末端数显著低于去卵巢手术组。结论:中等强度运动可以抑制去卵巢导致的大鼠股骨头骨松质骨量的丢失,确保其骨结构的维持,保证其正常的骨强度。更多还原

【Abstract】 Objective:To study the effect of treadmill exercise of moderate intensity on the structure of the femoral head spongy bone in ovariectomized rats,and to investigate the effect of exercise on osteoporosis in postmenopausal women.Methods:SD rats were randomly divided into sham operation group,ovariectomized group,estrogen control group and exercise group.Sham operation group was performed a simulated operation,but the ovaries were not removed.The other groups were subject to bilateral ovariectomy and treated for eight weeks beginning at two-week after the surgery.Estrogen control group was treated with nylestriol,and exercise group exercised in accordance with the requirements.The images of the femoral head spongy bone were captured to the computer memory by stereomicroscope after resin embedding,and histomorphometry indexes were measured by computer software.Results:In exercise group,trabecular bone area,trabecular bone thickness and trabecular bone number were significantly higher than that in ovariectomized group;trabecular bone separation and number of the trabecular bone terminal were significantly lower than that in ovariectomized surgery group.Conclusion:Moderateintensity exercise can inhibit bone mass loss of femoral head spongy bone caused by the ovariectomy in rats so as to ensure the maintenance of bone structure and the normal bone strength.更多还原