【摘要】 目的:探讨胎盘生长因子(placental growth factor,Pl GF)和可溶性血管内皮生长因子受体-1(soluble fmslike tyrosine kinase-1,s Flt-1)与子痫前期发病的关系。方法:采用电化学发光免疫分析法分别检测84例正常妊娠孕妇(对照组)﹑60例子痫前期孕妇的血清Pl GF和s Flt-1浓度。结果:子痫前期组血清Pl GF浓度[24-28周(56.20±30.29pg/ml)、29-33周(246.80±114.98 pg/ml)、34-36周(105.71±25.80 pg/ml)、37-周(78.36±46.70 pg/ml)]明显低于正常妊娠组[24~28周(632.33±225.23 pg/ml)(P﹤0.001)、29~33周(783.48±311.65 pg/ml)(P﹤0.001)、34~36周(643.71±252.04 pg/ml)(P﹤0.001)、37-周(387.76±183.79 pg/ml)(P﹤0.001)﹞,血清s Flt-1浓度[24~28周(5208.40±1 278.25pg/ml)、29~33周(6 196.00±2 051.28 pg/ml)、34~36周(9 941.86±2 912.66 pg/ml)、37-周(10 819.93±2591.38 pg/ml)]明显高于正常妊娠组[24-28周(2 560.76±1 058.33 pg/ml)(P﹤0.001)、29~33周(4 468.57±1502.19 pg/ml)(P﹤0.01)、34~36周(5124.38±1653.75 pg/ml)(P﹤0.001)、37-周(6 880.33±2 854.29 pg/ml)(P﹤0.01)]。结论:血清Pl GF和s Flt-1与子痫前期发病密切相关,可作为早期预测子痫前期的手段。更多还原

【Abstract】 Objective To investigate the relationship between placental growth factor and soluble vascular endothelial growth factor receptor- 1 and preeclampsia. Method The serum levels of PlG F and sF lt- 1 in 84 healthy pregnant women( control group)and 60 women with preeclampsia were determined by Electro chemiluminesc ence immunoassay. Results The levels of PlG F in serum were significantly lower in the women with preeclampsia [24- 28 weeks( 56. 20 ± 30. 29 pg / ml),29- 33 weeks( 246. 80 ±114. 98 pg / ml),34- 36 weeks( 105. 71 ± 25. 80 pg / ml),37- week( 78. 36 ± 46. 70 pg / ml) ] than in healthy controls [24- 28weeks( 632. 33 ± 225. 23 pg / ml)( P < 0. 001),29- 33 weeks( 783. 48 ± 311. 65 pg / ml)( P < 0. 001),34- 36 weeks( 643. 71 ±252. 04 pg / ml)( P < 0. 001),37- week( 387. 76 ± 183. 79 pg / ml)( P < 0. 001) ]. The sF lt- 1 levels were significantly higher in the women with preeclampsia [24- 28 weeks( 5 208. 40 ± 1 278. 25 pg / ml),29- 33 weeks( 6 196. 00 ± 2 051. 28 pg / ml),34- 36weeks( 9 941. 86 ± 2 912. 66 pg / ml),37- week( 10 819. 93 ± 2 591. 38 pg / ml) ] than in healthy controls [24- 28 weeks( 2560. 76 ± 1 058. 33 pg / ml)( P < 0. 001),29- 33 weeks( 4468. 57 ± 1 502. 19 pg / ml)( P < 0. 01),34- 36 weeks( 5124. 38 ± 1 653. 75 pg / ml)( P < 0. 001),37- week( 6 880. 33 ± 2 854. 29 pg / ml)( P < 0. 01) ]. Conclusion The serum levels of PlG F and sF lt- 1 are closely related to the pathogenesis of preeclampsia,which can be used as a way to predict the preeclampsia.更多还原