4-Methyl-2-(4-methylphenyl)-5-(2-thiazolinyl)-1,3-thiazole, a novel compound, was synthesized by the annulation of 5-hydroxyethylcarbamoyl-4-methyl-2-(4- methylphenyl)-1,3-thiazole with P_2S_5. 5-Hydroxyethylcarbamoyl-4-methyl-2-(4-methylphenyl)-1,3-thiazole was prepared from the starting material of p-tolunitrile. The newly synthesized compounds were characterized by elemental analysis, IR, NMR(~1H, ~(13)C) and MS spectra. Hence, the crystal of the title compound was obtained, and its structure was determi...
【英文摘要】
4-Methyl-2-(4-methylphenyl)-5-(2-thiazolinyl)-1,3-thiazole, a novel compound, was synthesized by the annulation of 5-hydroxyethylcarbamoyl-4-methyl-2-(4- methylphenyl)-1,3-thiazole with P_2S_5. 5-Hydroxyethylcarbamoyl-4-methyl-2-(4-methylphenyl)-1,3-thiazole was prepared from the starting material of p-tolunitrile. The newly synthesized compounds were characterized by elemental analysis, IR, NMR(~1H, ~(13)C) and MS spectra. Hence, the crystal of the title compound was obtained, and its structure was determi...
【基金】
supported by the Open-end Funds of Jiangsu Key Laboratory of Marine Biotechnology,Huaihai Institute of Technology(2013HS004);
Open-end Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(2015HYB05);
a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(201402)
【更新日期】
2016-05-11
【分类号】
O626
【正文快照】
1 INTRODUCTION
Thiazoline and thiazole rings as structural motifs have been found in numerous natural products[1]. For example, the cyclic depsipeptide Largazole separated from a cyanobacterium of the genus Symploca is composed of a substituted 4-methylt
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