In order to achieve real-time imaging with superresolution optical fluctuation imaging(SOFI),a novel SOFI algorithm combined with image filtering is proposed.Muti-frame images should be filtering processing,and the super-resolution images with high signal-noise ratio are obtained utilizing SOFI algorithm depending on temporal self correlations of fluorescent particles in muti-frame images.The result show that the SOFI algorithm based on spatial Gaussian filter can get a high signal-noise ratio super-resolut...