【摘要】 目的 探讨中国南方汉族人群NADPH氧化酶p22phox亚基基因(CYBA)C242T多态性和精神分裂症的易感性及疾病严重程度的关联。方法 本研究利用SNaPshot技术对906例中国南方汉族人群精神分裂症患者和982名健康对照者进行CYBA基因C242T多态性检测,采用阳性与阴性症状量表(PANSS)对患者组进行精神症状严重程度评定。结果(1)CYBA基因C242T多态性位点基因型频率和等位基因频率在精神分裂症患者和健康人群中的分布差异无统计学意义(P>0.05);(2)C242T多态性位点CT+TT基因型患者PANSS量表的阴性量表分及总分高于CC基因型患者(P<0.05)。结论 CYBA基因C242T多态性与中国南方汉族精神分裂症的易感性无明显关联,C242T多态性位点T突变可能会加重精神分裂症患者的阴性症状。更多还原

【Abstract】 Objective To investigate the potential association between the C242 T polymorphism of CYBA gene and risk,severity of schizophrenia.Methods Multiplex SNaPshot was used to determine the genotype and allele frequencies of CYBA gene C242 T in 906 schizophrenic patients and 9β₂ controls.Psychotic symptoms were evaluated in accordance with structured interview for the Positive and Negative Symptom Scale（PANSS）.Results（1） There were no significant differences in genotype and allele frequencies for C242 T polymorphism between the cases and controls（P > 0.05）.（2）The C242 T polymorphism C/T and T/T carriers had higher negative symptom scores and total scores than C/C carriers（P <0.05）.Conclusions There were no association between the C242 T polymorphism of CYBA gene and risk of schizophrenia.C242 T mutation of T may aggravate the negative symptoms of schizophrenia patients.更多还原