【摘要】 目的比较国产腮腺炎单价疫苗与进口含腮腺炎成分的联合疫苗(MMR)在免疫原性的差异,并系统分析国产腮腺炎单价疫苗保护效果,为免疫规划工作提供科学依据。方法检索中国生物医学文献光盘数据库、中国期刊全文数据库、维普中文科技期刊、万方数字化期刊、Pubmed、EMbase、Web of Science等数据库,筛选符合研究目的的文献,对符合纳入标准的文章采用Stata10.0进行Meta分析。结果提取8篇关于含腮腺炎疫苗成分的国产单价疫苗与进口联合疫苗接种后抗体阳转情况比较的文献资料,分析结果显示:国产单价疫苗和进口MMR组接种后腮腺炎抗体阳性率差异无统计学意义[RR=1.01,95%CI(0.95,1.07),P=0.780];入选的8篇文章均比较了国产单价疫苗的接种组和未接种组的保护效果的研究,合并后接种组腮腺炎发病率和未接种组腮腺炎发病率差异有统计学意义[OR=0.16,95%CI(0.06,0.45),P<0.001],接种国产单苗发病率显著低于未接种组,其疫苗保护率为84%。结论国产单价疫苗在免疫原性方面和进口MMR无统计学差异,国产单价腮腺炎疫苗对预防儿童腮腺炎有保护作用。更多还原

【Abstract】 Objective To provide the scientific basis for immunization programs work, systematic analyzed the differences between mumps monovalent vaccine and combined vaccine(MMR) in immunogenicity; and the protective effect of monovalent vaccine was also analyzed. Methods Pubmed、EMbase、SCI、Web of Science、CNKI and some other databases were searched for literatures published. Articles were identified using the Medical Subject Headings term "mumps", "Vaccine effectiveness". The software Stata(Version10.0) was used for meta-analysis. Results According to the selection and exclusion, eight literatures compared the seroconversion rate of domestic mumps vaccine and imported MMR were identified in the study. The result shows that there is no statistically difference in the seroconversion rate between domestic mumps vaccine group and imported MMR group [RR=1.01, 95%CI(0.95,1.07), P=0.780]. All of the authors of the eight literatures did the research of the mumps incidence comparison. After combining all data, we got the result that the mumps incidence is 84% of domestic mumps vaccine group, which is much higher than non-vaccinated children, and the difference is statistically significant [OR=0.16, 95%CI(0.06, 0.45), P<0.001]. Conclusion There are no significant differences between domestic monovalent vaccine and imported MMR in immunogenicity aspects.Domestic mumps vaccine play a positive role in protecting children from mumps-virus.更多还原