【摘要】 目的研究白细胞介素1α(IL-1α)、白细胞介素6(IL-6)的表达在颅咽管瘤中的临床意义。方法选择本院神经外科行外科手术切除的颅咽管肿瘤标本57例,通过免疫组化染色检测其组织标本中IL-1α,IL-6的表达情况,分析其表达情况与颅咽管瘤的病理类型、术后复发率及切除率的关系。结果本次实验57例组织标本中,40例全切除(70.2%),9例次全切除(15.8%),8例大部切除(14.0%);IL-6阳性表达25例,其阳性表达率与肿瘤是否全切除有统计学差异(P=0.039),与病理类型、是否复发无统计学差异(P>0.05);IL-1α仅在乳头鳞状型颅咽管瘤中阳性表达2例,其阳性表达率与病理类型、是否复发及肿瘤是否全切除均无统计学差异(P>0.05))。结论颅咽管瘤与其周围脑组织炎性反应的发生可能是颅咽管瘤手术难以全切除的重要因素,其中IL-6参与了这种炎性反应的发生。更多还原

【Abstract】 Objective To explore the expressions of interleukin( IL)-1α and IL-6 in craniopharyngiomas.Methods 57 pathologic specimens of craniopharyngiomas were collected in our hospital from the surgery. The expressions of IL-1α and IL-6 were detected by immunohistochemistry and the correlation between the expressions of IL-1α,IL-6 and the pathological types,removal rate and recurrence rate were analyzed. Results In 57 cases,40 cases was total removal( 70.2%),9 cases was subtotal removal( 15.8%),8 cases was partial removal( 14.0%); 25 cases was detected to be positive for IL-6,its positive expression has significant difference with tumor removal types( P = 0.039),however,its expression has no statistically significance with different pathological subtypes and postoperative recurrence( P>0.05); IL-1α only has positive expression in 2 cases,its positive expression with different pathological subtypes,postoperative recurrence and tumor removal types has no statistically significance( P> 0.05). Conclusion The inflammatory reaction in craniopharyngioma and its surrounding tissues may be the important factor of total removal of the tumor tissues,and IL-6 may involve this inflammatory reaction.更多还原