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滴定分析法与抑制型离子色谱法测定碳酸氢钠林格注射液中碳酸氢根离子的比较

Comparative study on the determination of bicarbonate in Bicarbonated ringer’s injection by Titrimetric method and Suppressed ion chromatography

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【作者】 刘路路黎伟郑波毛声俊金辉

【Author】 LIU Lulu;LI Wei;ZHENG Bo;MAO Shengjun;JIN Hui;West China School of Pharmacy,Sichuan University;West China School of Public Health,Sichuan University;

【机构】 四川大学华西药学院四川大学华西公共卫生学院

【摘要】 目的比较研究滴定分析法与抑制型离子色谱法测定碳酸氢钠林格注射液中碳酸氢根离子的方法学。方法分别采用两种方法测定碳酸氢根离子并进行方法学验证,比较二者的标准曲线、精密度和回收率等参数。结果滴定分析法与离子色谱法的线性回归方程分别为:Y=7.400X+0.1386(r=0.9997)、Y=0.9373X+0.5442(r=0.9999),线性范围均为0.890~2.046 mg·m L-1;日内RSD分别为0.4%、3.4%,日间RSD分别为0.3%、4.6%,平均回收率分别为99.7%(RSD=1.3%,n=9)、104.7%(RSD=7.5%,n=9)。结论滴定分析法的线性、精密度及回收率良好,更适合测定碳酸氢钠林格注射液中碳酸氢根的含量。

【Abstract】 OBJECTIVE To compare the determination of bicarbonate in Bicarbonated ringer’s injection by Titrimetric method and Suppressed ion chromatography.METHODS The methods were validatied on determining the bicarbonate and their standard curves,precisions and recoveries were compared.RESULTS The linear regression equations of Titrimetric method and Suppressed ion chromatography were Y = 7.400 X + 0.1386(r = 0.9997) and Y = 0.9373 X + 0.5442(r = 0.9999) within the range of 0.89-2.046mg·m L-1,the intra-day RSD of Titrimetric method and Suppressed ion chromatography were 0.4% and 3.4%,the inter-day RSD were 0.3% and 4.6%.The average recoveries were 99.7%(RSD = 1.3%,n = 9) and 104.7%(RSD = 7.5%,n = 9),respectively.CONCLUSION The results indicated that Titrimetric method had better linearity,precision and accuracy than Suppressed ion chromatography.Titrimetric method is suitable for the determination of bicarbonate in Bicarbonated ringer’s injection.

  • 【文献出处】 华西药学杂志 ,West China Journal of Pharmaceutical Sciences , 编辑部邮箱 ,2016年03期
  • 【分类号】R927.2
  • 【被引频次】5
  • 【下载频次】429
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