【摘要】 目的探讨明胶溶液添加量对α-磷酸三钙(α-tricalcium phosphate,α-TCP)骨水泥体系性能的影响。方法将不同比例的明胶溶液与α-TCP骨水泥体系调和,测量各组骨水泥试样的抗弯强度和抗压强度,与未添加明胶溶液的对照组进行比较。将力学强度提高最大的一组与对照组进行防水性能、凝固时间和电镜下表面形貌图对比观察。结果当明胶溶液与骨水泥调和液体积比(V明胶溶胶液∶V骨水泥调和液)=25∶100时,骨水泥试样的抗压强度和抗弯强度最大。与对照组相比,抗压强度由(7.874 54±0.660 97)MPa提高到(9.936 52±0.433 17)MPa,差异有统计学意义(P<0.05);抗弯强度由(5.157 06±0.298 30)MPa提高到(7.959 71±0.281 63)MPa,差异有统计学意义(P<0.05)。初凝时间由3min延长到5min,而终凝时间仍为13min。同时骨水泥防水性能增强,形成的羟基磷灰石晶体更加密集、均匀。结论适宜的明胶溶液添加比例可以提高α-TCP骨水泥的力学性能、防水性能,并获得更适合临床应用的凝固时间。更多还原

【Abstract】 Objective To determine the effects of gelatin on the performance of calcium phosphate cement(CPC).Methods α-tricalcium phosphate(α-TCP)bone cement was mixed with different concentrations of gelatin solutions.The CPC samples were soaked into simulated body fluid for one day before their compressive and bending strengths were measured. We also compared their waterproof performance,solidification time and surface topography.Results Gelatin solutions changed the performance of CPC.Optimal performance of CPC was achieved when the volume ratio of gelatin solution to CPC(Vgelatin solution∶VCPC liquid)was set at 25∶100,which increased compressive strength from(7.874 54±0.660 97)MPa to(9.936 52±0.433 17)MPa and bending strength from(5.157 06±0.298 30)MPa to(7.959 71±0.281 63)MPa.Gelatin solution also prolonged setting time of CPC,improved its waterproof performance,and promoted formulation of more dense and uniform hydroxyapatite crystals.Conclusion Gelatin can improve the compressive and bending strengths of CPC,and make CPC more suitable for clinic use through improvements in setting time and waterproof performance.更多还原