【摘要】 对硫辛酸制备工艺中水相法纯化过程进行了研究,结果表明硫辛酸钠具有表面活性,若其浓度高于临界胶束浓度,则会加剧硫辛酸聚集,不利于结晶,进而发生聚合反应生成黏稠物质。因此,需要加大水量,降低硫辛酸钠的浓度,当浓度低于临界胶束浓度时,收率会大幅增加。采用电导法测定硫辛酸钠的临界胶束浓度为0.253 mol/L,对应的水量为19.2倍,这与测定硫辛酸水量与收率关系的工艺实验得到的最适宜水量正好吻合。更多还原

【Abstract】 The process of purifying lipoic acid in water was studied in this paper. The surface activity of lipoic acid sodium was detected,which had a great effect on preparation of solvent-free lipoic acid. When the concentration of lipoic acid sodium was above the critical micelle concentration( CMC),micelles would be formed. Lipoic acid was wrapped up in the micelles,which was not conducive to crystallization and the polymerization of lipoic acid could be performed more easily. When the concentration of lipoic acid sodium was reduced to below the CMC by adding more water,the yield of lipoic acid would be increased obviously. The CMC of lipoic acid sodium was 0. 253 mol / L which was measured by the conductivity method,and the corresponding quantity of water was 19. 2 times. The result was in agreement with the best quantity of water in the purification experiments.更多还原