利用真实溶剂似导体屏蔽模型(conductor-like screening model for real solvents,COSMO-RS)预测发现异丙醇可以作为L-丙氨酰-L-谷氨酰胺的结晶工艺中的优化溶剂,并通过实验加以验证;研究了L-丙氨酰-L-谷氨酰胺在水-异丙醇二元体系中从293.15 K至318.15 K的溶解度和相关溶液热力学性质;使用修正Apelblat方程,λh方程,van’t Hoff方程以及(NIBS)Redlich-Kister方程对溶解度数据进行拟合;通过水/异丙醇体系结合冷却-溶析耦合结晶工艺获得形态改善的L-丙氨酰-L-谷氨酰胺晶体。
【英文摘要】
The conductor-like screening model for real solvents(COSMO-RS) was used to predict appropriate solvent for the crystallization process of L-alanyl-L-glutamine in this paper. As a result of the prediction,isopropanol was applied to the process as the optimal solvent which was verified by experiments.The solubility data and solution thermodynamic properties of L-alanyl-L-glutamine were measured from~293. 15 K to 318. 15 K in the isopropanol-water binary systems. Then the modified Apelblat equation,λh equation...
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