【摘要】 目的 :探讨传染性单核细胞增多症(IM)患儿合并肝损害的临床特点及相关因素。方法 :回顾分析2011年1月~2016年5月我院收治的144例IM患儿的临床资料。血清丙氨酸氨基转移酶(ALT)测定采用速度法,血清C反应蛋白(CRP)测定采用免疫比浊法,白细胞计数(WBC)测定采用电阻抗法,肝脏肿大采用肝脏B超判断,CD4+细胞计数、CD8+细胞计数、CD4+细胞/CD8+细胞比值测定采用流式细胞仪法。结果 :1 144例IM患儿,其中75例患儿血清ALT大于其参考区间上限(45U/L),占比52.08%。2血清ALT异常的75例IM患儿,45U/L<血清ALT<90U/L共31例(41.33%),90U/L≤血清ALT<200U/L共29例(38.67%),血清ALT≥200U/L共15例(20.00%)。144例IM患儿肝损害发生率为30.56%(44/144)。3肝损害患儿组与非肝损害患儿组性别、血清CRP相比差异无显著性,肝损害患儿组年龄、WBC、肝脏肿大阳性率、CD8+细胞计数显著高于非肝损害患儿组,CD4+细胞计数、CD4+细胞/CD8+细胞比值显著低于非肝损害患儿组,差异有显著性。结论 :IM患儿肝损害与患儿年龄、WBC、肝脏肿大、CD8+细胞计数、CD4+细胞计数、CD4+细胞/CD8+细胞比值等指标相关。更多还原

【Abstract】 Objective to discuss the children with infectious mononucleosis(IM)the clinical characteristics of liver damage and related factors.Methods retrospective analysis in January 2011-in May 2016 in our hospital clinical data of 144 cases of children with IM.Determination of serum alanine aminotransferase(ALT)USES the velocity method, determination of serum c-reactive protein(CRP)by immune turbidimetry, white blood cell count(WBC)determination of the resistance Kang Fa, hepatomegaly with hepatic B to exceed, CD4+cell count, CD8+cell count, determination of the ratio of CD4+/CD8+cells by flow cytometry instrument method.Results(1), 144 cases of children with IM, of which 144 cases of children with serum ALT is greater than the reference range(45 u/L), accounted for 52.08%.(2)for children with 75 cases of abnormal serum ALT IM 45u/L serum ALT < < 90 u/L, a total of 31 cases(41.33%), 90 u/L or less serum ALT < 200 u/L, a total of 29 cases(38.67%), serum ALT 200 u/L or a total of 15 cases(20.00%).The incidence of 144 cases of children with IM liver damage was 30.56%(44/144).Liver damage(3)the group with the children with liver damage in children with gender, there was no significant difference compared with serum CRP, liver damage in children with group of age, the WBC, hepatomegaly, positive, CD8+cell count liver damage is significantly higher than the children group, CD4+cell count and CD4+/CD8+cells ratio was significantly lower than the children with liver damage group, with significant difference.Conclusion IM with liver damage and age, the WBC, hepatomegaly, CD8+cell count and CD4+cell count and CD4+/CD8+cells ratio and other related indicators.更多还原