【摘要】 目的探讨血清高迁移率族蛋白B(HMGB1)与颈动脉易损斑块合并短暂性脑缺血发作(TIA)的相关性。方法本研究共纳入144例颈动脉易损斑块患者,根据是否合并TIA分为合并TIA组(A组,n=48)及未合并TIA(B组,n=96),另设颈动脉稳定斑块患者(C组,n=60)及正常健康人群组(D组,n=45)为对照组,采用酶联免疫吸附(ELISA)法测量各组血清高迁移率族蛋白B1水平。结果 A组血清HMGB1水平显著高于B组[(8.75±1.46)ng/mL vs(5.12±30.64)ng/mL],B组血清HMGB1水平显著高于C组[(5.12±30.64)ng/mL vs(2.35±0.42)ng/mL],上述3组血清HMGB1水平显著高于D组的(1.38±0.21)ng/mL,差异均有统计学意义(P<0.05)。多元Logistic回归分析显示,高血清HMGB1水平与颈动脉易损斑块合并TIA呈独立相关(优势比2.374,95%可信区间1.264~3.982;P<0.01)。结论血清高迁移率族蛋白B1水平的升高有助于评估颈动脉易损斑块患者发生TIA的风险。更多还原

【Abstract】 Objective To explore the correlation between serum high mobility group protein box-1(HMGB1)level and vulnerable carotid plaque in patients with transient ischemic attack(TIA).Methods A total of 144 patients with vulnerable carotid plaque were included in this study,who were classified as TIA-combined group(group A,n=48)and non-TIA group(group B,n=96).We selected another 60 cases with stable carotid plaque as group C and 45 healthy controls as group D.Serum HMGB1 levels of each group were detected by enzyme-linked immunosorbent assay(ELISA).Results The serum HMGB1 level in the group A was higher than that in the group B[(8.75±1.46)ng/mL versus(5.12±30.64)ng/mL],which showed higher level than group C[(5.12±30.64)ng/mL versus(2.35±0.42)ng/mL)],and all the above-mentioned groups showed higher level than group D(1.38±0.21)ng/mL,all differences were significant(P<0.05).Multivariate Logistic regression demonstrated that higher HMGB1 level was independently associated with the presence of vulnerable carotid plaque in patients with TIA(OR=2.374,95% CI:1.264 to 3.982,P<0.05).Conclusion The higher level of serum HMGB1 may contribute to the assess the risk of TIA for the patients with the presence of vulnerable carotid plaque.更多还原