【摘要】 目的分析急性脑梗死患者颈动脉粥样硬化斑块性质与白细胞介素-6(IL-6)、C反应蛋白(CRP)表达水平的关系。方法选择急性脑梗死患者95例(观察组)为研究对象,根据颈动脉彩色多普勒超声检测结果分为不稳定斑块组(29例)、稳定斑块组(31例)及无斑块组(35例),选择同时期健康人30例为正常对照组,测定4组研究对象血清中IL-6、CRP的水平并进行比较。结果观察组CRP(4.80±2.16)mg/L和IL-6(209.54±75.60)pg/mL水平显著高于正常对照组的(2.43±0.51)mg/L和(103.34±8.99)pg/mL(P<0.05)。不稳定斑块组CRP、IL-6水平均高于稳定斑块组、无斑块组和对照组(P<0.05);稳定斑块组高于无斑块组和对照组(P<0.05)。CRP、IL-6水平与动脉粥样硬化斑块的不稳定性呈正相关(rCRP=0.740,rIL-6=0.924,均P<0.05)。结论急性脑梗死患者颈动脉粥样硬化斑块性质与IL-6、CRP表达水平密切相关,可能在预测脑血管病的发生及防治中起重要作用。更多还原

【Abstract】 Objective To observe the relationship of expression level of carotid atherosclerosis plaque and interleukin-6(IL-6),C-reactive protein(CRP)in patients with of acute cerebral infarction.Methods Ninety-five patients with acute cerebral infarction(observation group)treated in the hospital were selected as the research objects,and were divided into unstable plaque group(29cases),stable plaque group(31cases)and non plaque group(35cases)according to the detection results of color Doppler ultrasound of carotid artery,and select healthy people of 30 cases as the control group,the serum IL-6,CRP levels in 4groups were determined and the differences were compared.Results The levels of IL-6,CRP in the observation group were(4.80±2.16)mg/L,(209.54±75.60)pg/mL and significantly higher than that in control group(2.43±0.51)mg/L,(103.34±8.99)pg/mL,P<0.05.The CRP,IL-6levels in unstable plaque group were higher than the stable plaque group,non plaque group and control group,P<0.05.The stable plaque group was higher than non plaque group with a statistically significant difference,P<0.05.CRP,IL-6levels were positively correlated with the instability of atherosclerotic plaques(rCRP=0.740,rIL-6=0.924,P<0.05).Conclusion The serum levels of IL-6and CRP in patients with acute cerebral infarction are closely related to the unstable plaque,IL-6and CRP may play critical role in the prevention and treatment of acute cerebral infarction.更多还原