【摘要】 目的探讨VEGF-C及VEGFR-3与NSCLC淋巴转移间的关系,为了解患者预后提供依据。方法采用免疫组化法检测65例NSCLC中VEGF-C及VEGFR-3的表达,结合临床病理特征进行分析。结果 NSCLC中VEGF-C和VEGFR-3的阳性率明显高于正常肺组织(P<0.05)。二者在Ⅲ期NSCLC中的表达率明显高于Ⅰ、Ⅱ期,且随病理分级的增高而显著增加(P<0.05),在有淋巴结转移者明显高于无淋巴结转移者(P<0.05)。结论 VEGF-C及VEGFR-3在NSCLC中高表达,与其临床分期、病理分级、病理类型和淋巴结转移均密切相关。更多还原

【Abstract】 Objective To study relationship between VEGF- C,VEGFR- 3 expression and lymphatic metastasis in patients with non- small cell lung cancer( NSCLC) to know the prognosis of patients. Methods Immunohistochemical staining was used to detect the expression of VEGF- C and VEGFR- 3 in 65 cases of NSCLC. The significance of VEGF- C and VEGFR- 3 expression was analyzed with their clinicopathological parameters. Results The postive rates of VEGF- C and VEGFR- 3 expression were higher in NSCLC than those in nomal lung tissue( P < 0. 05). The expression rates of VEGF- C and VEGFR- 3 were higher in clinical stage Ⅰ,Ⅱ than those in stage Ⅲ,and which were increased with the grading( P < 0. 05). And the expressions were higher in patients with lymph node involvement than those without metastasis( P < 0. 05). Conclusion In NSCLC,the abnormal expressions of VEGF- C and VEGFR- 3 had obvious relationship to clinical stage,pathological grade,lymph node involvement.更多还原