【摘要】 目的探讨奥沙利铂联合替吉奥(SOX方案)化疗后对进展期胃癌手术切除的影响。方法选取我院2012年7月至2015年2月进展期胃癌行奥沙利铂联合替吉奥(SOX方案)化疗后并施行手术的患者20例为联合组;同时随机收集进展期胃癌未行化疗遂施行手术的患者20例为对照组。分析总结所有数据资料,分析比较2组的手术切除率、术后淋巴结转移数目、平均住院日。结果联合组20例患者手术切除率高达95%;对照组手术切除率仅为70%,差异有统计学意义(P<0.05);联合组与对照组比较,淋巴结转移数目、平均住院日差异均有统计学意义(P<0.05)。结论进展期胃癌术前使用奥沙利铂联合替吉奥方案化疗后再施行手术治疗,可获得较好的临床疗效。更多还原

【Abstract】 Objective To explore the effect of oxaliplatin combined with S-1( SOX) chemotherapy on the resection of advanced gastric cancer. Methods Twenty patients with advanced gastric cancer,who first underwent oxaliplatin combined with S-1chemotherapy and then received surgery,were recruited as the combined treatment group,while another 20 surgical patients with advanced gastric cancer who did not have chemotherapy were assigned as the control group. The surgical resection rate,the number of postoperative lymphatic node metastasis and the average length of stay in the hospital were compared between the patients of the 2groups. Results The surgical resection rate in the 20 patients of the combined treatment group was as high as 95%,while that of the control group was just 70%. Statistical significance could be found,when comparisons were made between them( P < 0. 05). There were statistical differences in the number of postoperative lymphatic node metastasis and the average length of stay,when comparisons were made between the combined treatment group and the control group( P < 0. 05). Conclusion The application of combined chemotherapy with oxaliplatin and S-1 before surgery could achieve better clinical therapeutic effects.更多还原