【摘要】 探究了次氯酸钠(Na Cl O)对萘普生(NPX)的氧化降解效果。分析了次氯酸钠投加量对NPX去除率和体系总有机碳(TOC)的影响,同时分析了此过程中次氯酸钠投加量与次氯酸钠利用效率之间的关系。结果表明,NPX的降解率随着次氯酸钠投加量增加而增加,直至NPX的降解率达100%。溶液中TOC去除率随Na Cl O与NPX摩尔比的增大先增加后趋于平缓,最后溶液中TOC去除率稳定在22.5%左右。次氯酸钠的利用效率会随Na Cl O与NPX摩尔比的增大先增后减,在Na Cl O与NPX摩尔比为7.5∶1时,次氯酸钠的利用效率达最大值。同时研究了不同pH对NPX氧化降解反应的影响,实验显示,溶液处于较低的pH更有利于NPX被氧化降解。最后通过对比实验,研究了医用萘普生胶囊中所添加辅料对NPX的氧化反应的影响,结果表明,萘普生医用药品中所添加成分对NPX的氧化降解有一定的抑制作用。更多还原

【Abstract】 In this study,the oxidative degradation of naproxen( NPX) was investigated by sodium hypochlorite( Na Cl O). The impacts of sodium hypochlorite dosages on NPX degradation rates and concentration of total organic carbon( TOC) were analyzed. The utilization of sodium hypochlorite,different initial pH values and supplementary material in medical capsules on oxidative degradation reaction of NPX were also investigated during the experiments. The results demonstrated that the sodium hypochlorite dosages had a positive effect on the degradation rates of NPX,and presented a trend toward NPX degradation rates raised gradually with the increase of sodium hypochlorite dosages until the degradation rate was 100%. The removal rate of TOC increased with the increasing mole ratio of Na Cl O to NPX before it stabilized at about 22. 5%. The utilization of Na Cl O increased firstly and then decreased with the increasing mole ratio of Na Cl O to NPX,and reached the maximum when the mole ratio was 7. 5 ∶ 1. The controlled experiments illustrated that the solution with low pH value accelerated the oxidation degradation of NPX,but the supplementary material in medical naproxen capsules had opposite effects.更多还原