【摘要】 目的:探索辛伐他汀联合辅酶Q10对慢性心衰大鼠心功能及心室重构的影响。方法:利用腹主动脉缩窄法制作雄性SD大鼠慢性心力衰竭模型,随机分为模型组、辛伐他汀组、辅酶Q10组、联合用药组,另设假手术组,每组8只大鼠,测量各组大鼠血流动力学参数(LVEDP、±dp/dtmax);计算左心室质量指数(LVMI)、检测左心室心肌胶原容积分数(CVF%);观察左心室心肌组织病理学改变。结果:与模型组相比,辛伐他汀组、辅酶Q10组和联合用药组LVEDP、LVMI和CVF等三项指标降低,差异具有统计学意义(P<0.01);且联合用药组较辛伐他汀、辅酶Q10单用组改变差异具有统计学意义(P<0.05)。结论:辛伐他汀与辅酶Q10联合应用较两药单独应用改善心衰大鼠心功能、抑制心室重塑作用明显。更多还原

【Abstract】 Objective: To investigate the effects of simvastatin combined coenzymeQ10 on ventricular remodeling and cardiac function in rats with chronic heart failure( CHF). Methods: 40 SD rats were randomly divided into five groups: sham- operated group,coenzymeQ10 group,simvastatin group,simvastatin combined coenzymeQ10 group and model group. Coarctation of abdominal aorta( CCA) except for the shame- operated group. Testing hemodynamic of left ventricular end-diastolic diameter press( LVEDP),left ventricular pressure rise and fall( ±dp / dtmax),left ventricular mass / body mass( LVMI); HE and Masson’s trichrome staining for morphology. Results: Compared with model group,hemodynamic analysis revealed that left ventricular end-diastolic pressure( LVEDP) were significantly lower in simvastatin group,coenzymeQ10,simvastatin combined coenzymeQ10 group( P < 0. 01),left ventricular pressure rise and fall increased remarkable( P < 0.01); In addition,left ventricular mass / body mass( LVMI) and collagen volume fraction( CVF%) was decreased sharply( P <0.01).CoenzymeQ10 group,simvastatin combined coenzymeQ10 groups improved CHF remarkable than rest groups( P < 0.05). Conclusion: All of these results verify that treatment with simvastatin combined coenzymeQ10 has more obvious effects on improving heart function of rats with cardiac remodeling and inhibit ventricular remodeling.更多还原