【摘要】 以系列羟基卟啉为原料,用对甲苯磺酰肼还原,再用四氯对苯醌氧化,制得二氢卟吩(2a~2d);以二环己基碳二亚胺为脱水剂,2与5-氟尿嘧啶-1-基乙酸经酯化反应合成了4个新型二氢卟吩-5-氟尿嘧啶化合物(3a~3d),总收率分别为6.9%,6.9%,7.0%和7.6%,其结构经UV-Vis,1H NMR,IR和MS表征。更多还原

【Abstract】 Chlorins( 2a ~ 2d) were synthesized by reduction with p-toluenesulfonhydrazide and oxidation with tetrachloro-p-benzoquinone,using hydroxylporphyrins as precursor. Then using N,N’-dicyclohexylcarbdiimide as dehydration agent,four novel chlorins-5-fluorouracil( 3a ~ 3d) were synthesized by esterification of 2a ~ 2d and 5-fluorouracil-1-yl acetic acid in total yield of 6. 9%,6. 9%,7. 0%and 7. 6%,respectively. The structures were characterized by UV-Vis,1H NMR,IR and MS.更多还原