【摘要】 目的探讨免疫联合疗法在结石性梗阻黄疸手术感染中的应用价值。方法选取92例结石性梗阻黄疸患者,随机分为试验组(A组)和对照组(B组),每组46例。所有患者均采用抗感染、胃肠减压及肠外营养支持等常规治疗;A组在此基础上再给予免疫调理治疗,治疗持续1周;治疗前和治疗后1、3、5、7、14 d,对患者淋巴细胞计数(LC)和人类白细胞抗原(HLA-DR)水平进行统计,并统计2组患者术后感染率。结果 2组不同治疗方法之间淋巴计数、HLA-DR比较,差异有统计学意义(P<0.05);2组不同时间淋巴计数、HLA-DR比较,差异有统计学意义(P<0.05),术后3 d、5 d、7 d,A组LC和HLA-DR水平高于B组(P<0.05);术后A组感染4例(8.7%),B组10例(26.1%),2组比较差异有统计学意义(P<0.05)。结论免疫联合疗法具有改善免疫抑制,促进免疫功能恢复的作用,应用于结石性梗阻性黄疸手术的患者中,可有效预防术后感染的发生。更多还原

【Abstract】 Objective To explore the application value of conventional therapy combined with immunotherapy in patients with calculous obstructive jaundice who received surgical operation. Methods Ninety- two patients with calculus obstruction jaundice were randomly divided into experimental group( group A) and control group( group B),with 46 patients in each group. All the patients were treated by conventional therapies including anti- infection,gastrointestinal decompression and parenteral nutrition support,however,the patients in group A,on the basis of conventional therapy,were treated by immunomodulatory therapy,with a treatment course of 1 week for both groups. The lymphocytes counts( LC) and the levels of human leukocyte antigens( HLA-DR) were detected before treatment and on 1d,3d,5d,7d,14 d after treatment,moreover,the postoperative infection rates were observed and compared between two groups. Results There were significant differences in lymphocytes counts and the levels of HLA-DR between two groups( F = 5. 783,P < 0. 05),moreover,there were significant differences in lymphocytes counts and the levels of HLA-DR in different time pionts between two groups( F =10. 425,P < 0. 01). Both LC and HLA-DR levels on 3d,5d,7d after treatment in group A were significantly higher than those in group B( P < 0. 05). The postoprative infection rate in group A was 8. 7%( 4 cases),however,which was 26. 1%( 10 cases) in group B,there was a significant difference between two groups( P < 0. 05). Conclusion The conventional therapy combined with immunotherapy can improve immune suppression and promote the recovery of the immune function,which can effectively prevent the occurrence of postoperative infection in patients with calculous obstructive jaundice.更多还原