【摘要】 目的探讨慢性偏头痛对患者工作记忆能力的影响。方法收集2013年1月至2014年11月来我院神经内科就诊且临床诊断为慢性偏头痛的患者64例(偏头痛组),同时选取来我院进行健康检查的健康志愿者64例作为对照组,先比较两组受检者的神经心理学评分,再采用韦氏记忆量表及N-back神经心理学测试方法对两组受检者的工作记忆能力进行比较。结果偏头痛组与对照组在简易智能量表评分、词语流畅性测验得分、焦虑自评量表评分及抑郁自评量表评分方面的差异均无统计学意义(P>0.05);偏头痛组和对照组受检者在故事理解[(2.75±0.63)分vs(3.23±0.74)分]、倒背数字[(2.91±0.51)分vs(3.15±0.59)分]、顺背数字[(1.48±0.43)分vs(1.72±0.61)分]及积累分测验[(2.64±0.67)分vs(3.25±0.56)分]方面的得分比较,偏头痛组低于对照组,差异均具有统计学意义(P<0.05);偏头痛组患者处理工作记忆之初级任务时的准确率比对照组高[(17.8±.1.6)%vs(17.0±1.2)%],而反应时间较对照组长[(694.2±168.4)ms vs(626.4±152.3)ms],差异均具有统计学意义(P<0.05);而两组受检者在高级任务时的准确率及反应时间方面比较差异均无统计学意义(P>0.05)。结论慢性偏头痛对患者故事理解、背数及积累分测试及时间初级处理方面有较大的影响,值得临床医师重视。更多还原

【Abstract】 Objective To observe the effect of chronic migraine on patients working memory capacity.Methods Sixty-four patients with chronic migraine(migraine group) in Department of Neurology in our hospital from January 2013 to November 2014 were collected. At the same time, 64 healthy volunteers were selected as the control group. The neuropsychological scores were compared between the two groups of subjects, and the working memory capacity between the two groups were compared by the Wechsler Memory Scale and N-back neural psychology test.Results There was no significant difference in the simple intelligence scale score, verbal fluency test score, self rating anxiety scale and self rating depression scale score between migraine group and control group(P>0.05). The scores of story comprehension(2.75 ± 0.63) vs(3.23 ± 0.74), digit backward(2.91 ± 0.51) vs(3.15 ± 0.59), digit forward(1.48 ± 0.43) vs(1.72±0.61) and accumulation test(2.64±0.67) vs(3.25±0.56) in migraine group were significantly lower than those the control group, and the differences were statistically significant(P<0.05). The primary task of working memory accuracy rate of patients in migraine group was significantly higher than that in control group with(17.8±.1.6)% vs(17.0±1.2)%,and the reaction time was significantly longer than that in control group with(694.2±168.4) ms vs(626.4±152.3) ms, and the difference was statistically significant(P<0.05). There was no significant difference in accuracy rate of advanced task and reaction time between the two groups(P>0.05). Conclusion Chronic migraine has great influence on the story understanding, back number, accumulation test and primary processing time, which should be paid attention to.更多还原