【摘要】 目的探讨乙型肝炎后肝硬化合并消化性溃疡与幽门螺杆菌感染的相关性。方法选择2014年1月至2016年1月深圳市盐田区人民医院收治的乙型肝炎后肝硬化患者180例为观察组,单纯性消化性溃疡患者130例作为对照组1组,600例健康体检者作为对照2组。比较各组HP感染率、观察组不同肝功能分级患者HP感染率以及观察组和对照1组不同类型消化性溃疡患者HP的感染率。结果观察组和对照2组患者的HP感染率分别为44.4%(80/180)和49.3%(296/600),均低于对照1组的77.7%(101/130),差异有统计学意义(χ~2=29.200、34.638,P<0.001)。观察组中Child-Pugh A级、B级和C级患者的HP感染率分别为37.2%(29/78)、45.0%(27/60)和57.1%(24/42),差异无统计学意义(χ~2=0.762,P=0.284)。观察组初发溃疡患者的HP感染率为64.5%(40/62),复发溃疡患者的HP感染率为70.4%(38/54),差异无统计学意义(χ~2=0.449,P=0.503);胃溃疡患者HP感染率为58.7%(27/46),十二指肠溃疡患者HP感染率为72.9%(52/70),分别低于对照1组患者的68.6%(35/51)和83.5%(66/79),但差异无统计学意义(χ~2分别为0.336、0.610,P值分别为1.415、0.087)。结论乙型肝炎后肝硬化患者HP感染率与正常人群差异无统计学意义,乙型肝炎后肝硬化合并消化性溃疡患者HP感染率低于单纯性消化性溃疡患者,HP感染并非乙型肝炎后肝硬化合并消化性溃疡的主要因素。更多还原

【Abstract】 Objective To investigate the correlation between hepatitis B virus related liver cirrhosis combined with peptic ulcer and Helicobacter Pylori(HP) infection.Methods Total of 180 patients with hepatitis B virus related liver cirrhosis from January 2014 to January 2016 in Yantian People’s Hospital were selected as the observation group,130 patients with simple peptic ulcer were selected as control group 1,and 600 cases of healthy physical examination were selected as control group 2.The infection rates of HP among all groups,among patients with different liver function classification in observation group and between patients combined with digestibility ulcer in observation group and control group 1 were compared,respectively.Results The HP infection rates of patients in observation group and control group 2 were 44.4%(80/180) and 49.3%(296/600),which were lower than those of the control group 1,respectively.The difference was statistically significant(χ~2=29.200,34.638;P<0.001).HP infection rates of patients with Child-Pugh A,B and C grade in observation group were 37.2%(29/78),45.0%(27/60) and 57.1%(24/42),respectively.The differences had no statistical significance(χ~2=0.762,P=0.284).In observation group,the rate of HP infection in patients with primary ulcer was 64.5%(40/62),which was lower than that of patients with recurrent ulcer [70.4%(38/54)],but the difference had no statistical significance(χ~2=0.449,P=0.503).In observation group,the rate of HP infection in patients with gastric ulcer was 58.7(27/46) and in patients with duodenal ulcer patients was 72.9%(52/70),which were lower than those of the patients in control group 1 [ 68.6%(35/51) and 83.5%(66/79)],respectively.The differences had no statistical significance(χ~2=0.336,0.610;P=1.415,0.087).Conclusions There was no statistical difference between HP infection rate in patients with hepatitis B related liver cirrhosis and normal people.The infection rate of HP in hepatitis B virus related liver cirrhosis patients combined with peptic ulcer is lower than that of patients with simple peptic ulcer.HP infection is not the main factor of hepatitis B virus related liver cirrhosis combined with peptic ulcer.更多还原