【摘要】 乙型病毒性肝炎由HBV感染引起,分为急性HBV感染和慢性HBV感染,慢性乙型肝炎(CHB)为多数亚太地区及中国肝病患者的常见表现。宿主免疫应答与病毒和病毒成分共同作用,导致CHB疾病进展,会经历3个不同时期:免疫耐受期、免疫清除期和免疫活动。全面了解CHB的免疫机制有助于乙型肝炎的抗病毒治疗。本文就HBV感染过程中的免疫分隔化、免疫耐受、Toll样受体及共刺激分子等免疫学机制的一些新进展进行综述。更多还原

【Abstract】 Hepatitis B virus(HBV) infection is a common cause of chronic hepatitis, and is divided into acute HBV infection and chronic HBV infection. In Asian-Pacific and China, almost all subjects with HBV infection exhibit chronic hepatitis B(CHB). CHB is a dynamic state of interaction between the virus and the host immune system. The natural course of CHB is generally divided into three phases, namely the immune tolerant phase, the immune clearance phase and the immune active phase. Finding the mechanism of immune response should improve the antiviral therapy for HBV infection. Here, we reviewed the new progress of immunology of HBV infection, including immune tolerance, immune compartmentalization, Toll-like receptor and viral clearance.更多还原