【摘要】 目的探讨美托洛尔缓释片对老年高血压伴慢性心衰患者的疗效及高敏C-反应蛋白的相关性。方法选取2014年8月~2015年10月来我院就诊的老年高血压伴慢性心衰患者患者125例,随机分为观察组63例及对照组62例。观察两组治疗前及治疗后的血压水平,临床疗效及hs-CRP,BNP水平。结果两组患者总有效率比较,观察组为92.06%,对照组为82.26%,两组差异显著(P<0.05)。两组患者治疗后与治疗前比较,SBP及DBP均显著下降,差异具有统计学意义(P<0.05)。观察组治疗后SBP及DBP均显著低于对照组治疗后,两组比较差异具有统计学意义(P<0.05)。两组患者治疗后hs-CRP及BNP水平皆比治疗前显著下降,差异具有统计学意义(P<0.05)。治疗组治疗后的hs-CRP及BNP水平明显低于对照组,两组差异具有统计学意义(P<0.05)。试验过程中两组均未见与本研究用药相关的不良反应发生。结论美托洛尔缓释片治疗老年高血压伴慢性心衰患者疗效显著,可以明显降低hs-CRP及BNP水平。更多还原

【Abstract】 Objective To explore the correlation of metoprolol sustained-release tablets with curative effect and high sensitive C-reactive protein in patients with chronic heart failure in elderly hypertensive patients. Methods From August 2014 to October 2015, 125 elderly patients with hypertension and chronic heart failure were randomly divided into observation group(63 cases) and control group(62 cases), the blood pressure level in two groups before and after treatment were observed, the clinical curative effect and the level of hs-CRP, BNP were observed and compared. Results The total effective rate of the two groups was compared, the rate of observation group was 92.06%, the rate of control group was 82.26%, and the difference was significant(P < 0.05). After treatment all the SBP and DBP were significantly decreased of two groups than before treatment, the difference was significant(P < 0.05). After treatment the patients’ SBP and DBP of observation group were significantly lower than the control group, the difference between the two groups was significant(P < 0.05). After treatment the hs-CRP and BNP levels were significantly decreased in the two groups than before treatment, and the difference was significant(P < 0.05). after treatment, hs-CRP and BNP level of treatment group s were significantly lower than the control group, the difference was significant(P < 0.05). No adverse reactions related to the drug use were found in the two groups during the experiment. Conclusion Metoprolol sustained release tablets in the treatment of elderly hypertensive patients with chronic heart failure patients with obvious curative effect, can significantly reduce the hs-CRP and BNP levels.更多还原