【摘要】 目的研究替硝唑和甲硝唑治疗加重型精神患者口腔感染的近期临床疗效及安全性。方法选择并纳入我院2013年11月~2015年8月加重型精神患者口腔感染患者68例,进行分组研究。Ⅱ组选用替硝唑治疗,Ⅰ组选用甲硝唑治疗。对比两组患者近期临床疗效及安全性。结果Ⅱ组近期临床疗效明显高于Ⅰ组,经比较差异有统计学意义(P<0.05);Ⅱ组患者恶心、呕吐、便秘、腹泻等副作用发生率明显低于Ⅰ组,组间数据差异有统计学意义(P<0.05)。Ⅱ组症状消除时间、伤口愈合时间均显著缩短,与Ⅰ组比较差异有统计学意义(P<0.05)。结论替硝唑在治疗加重型精神患者口腔感染中的近期临床疗效及安全性更好,值得推广。更多还原

【Abstract】 Objective To research the short-term clinical curative effect and safety of tinidazole combined with metronidazole in treatment of oral infection of patients with severe psychosis. Methods 68 severe psychosis patients with oral infection were admitted to our hospital from November 2013 to August 2015 were selected and they were allocated to group I and group Ⅱ.Group Ⅱ was treated by tinidazole while group I was treated by metronidazole.Short-term clinical curative effect and safety of patients in two groups were compared. Results The short-term clinical curative effect of patients in group Ⅱ was significantly higher than that of group I.Data of patients in two groups had significant difference which had statistical significance(P < 0.05).Incidences of side effects such as naus ea,vomiting,constipation,diarrhea of patients in group II were significantly lower than those of group I.Data of patients in two groups had significant difference which had statistical significance(P < 0.05).Symptom elimination time and wound healing time of group II were both shortened.Difference between two groups had statistical significance(P < 0.05). Conclusion Tinidazole in treatment of oral infection of patients with severe psychosis has better short-term clinical curative effect and safety,worthy of promotion.更多还原