【摘要】 目的:了解深圳市宝安区女性宫颈人乳头瘤病毒(HPV)感染及基因分型情况,探讨影响HPV感染的相关因素,为本地区更有效地开展宫颈癌防治提供依据。方法:采用聚合酶链式反应—反向斑点杂交法(PCR-RDB)对2015年1~12月自愿参加宫颈癌筛查的1 652例女性进行23种HPV-DNA检测,同时对筛查对象的一般情况进行问卷调查。结果:1 652例筛查对象中,HPV阳性266例,阳性率为16.10%,其中61例为混合型感染。高危型HPV感染最常见的亚型为HPV52、HPV16亚型,低危型HPV感染最常见的亚型为HPV43亚型。单因素分析结果示:年龄、户籍类型、文化程度、家庭经济收入、初次性行为年龄、初产年龄、怀孕次数、性伴侣数、伴侣性伴侣数为HPV感染的影响因素(P<0.05)。多因素非条件Logistic回归分析结果表明:家庭经济收入、初次性行为年龄、怀孕次数、性伴侣数为影响HPV感染的危险因素(P<0.05)。结论:HPV感染多见于家庭月平均收入低,初次性行为年龄早,怀孕次数多,性伴侣数多的女性人群,应重视对此类人群的筛查。更多还原

【Abstract】 Objective:To investigate the epidemiological features of female human papilloma virus(HPV)infection and genotype in Baoan district of Shenzhen city,and its influence factors were analyzed.Methods:1,652 women who volunteered for the cervical cancer screening from January 2015 to December 2015 were recruited.The cervical samples were collected and the HPV-DNA tests for 23high-risk genotypes were conducted by polymerase chain reaction-reverse dot blot(PCR-RDB).Each participant completed a questionnaire of general information.Results:Among 1,652 participants,266(16.10%)cases were positive in HPV-DNA test,and 61 cases were multiple infections.The most prevalent high-risk HPV genotypes were HPV-52 and HPV-16.The most prevalent low-risk HPV genotypes was HPV-43.Univariate analysis showed that the age,household type,educational level,family income,age of first sex,age of first delivery,number of pregnancies,number of sexual partners and number of partners of sexual partners were the factors affecting the infection of HPV(P <0.05).Multiple logistic regression analysis showed that family income,age of first sex,number of pregnancies,number of sexual partners were the risk factors affecting HPV infection(P <0.05).Conclusion:The women of low family income,early age of first sex,multiple pregnancy and more sexual partners were more likely to be infected by HPV,thus more attention should be paid for them.更多还原