【摘要】 目的研究三九膏的体外透皮吸收规律。方法通过Franz扩散池获得接收液,采用HPLC法测定芥子碱硫氰酸盐,计算三九膏的体外透皮吸收的累积渗透率,探究其拟合模型。结果三九膏中芥子碱硫氰酸盐12 h的累积渗透率在22%左右,体外透皮吸收规律符合希古契模型。结论三九膏中芥子碱硫氰酸盐累积透过量在时间上与临床治疗贴敷时间吻合,为三九膏临床治疗确定最适宜贴治时间提供了依据。更多还原

【Abstract】 Objective To study the absorption propertied of Sanjiu Plaster in vitro. Methods Franz diffusion pool was used to obtain receptor fluid, and sinapine thiocyanate was determined by HPLC method. Cumulative permeability was calculated to find out its fitting model. Results Cumulative permeability of sinapine thiocyanate from Sanjiu Plaster during 12 h was about 22%. The characteristics was accord to Higuhci fitting model in vitro. Conclusion Cumulative penetration amounts of sinapine thiocyanate in Sanjiu Plaster had the same period of time with sticking time, which can provide the basis for treatment.更多还原