【摘要】 狂犬病是由狂犬病病毒(rabies virus,RABV)感染中枢神经系统引起的致死性人畜共患传染病。RABV糖蛋白存在于病毒表面,它既是病毒的主要保护性抗原,诱导体液免疫产生中和抗体和刺激T细胞产生细胞免疫,又是病毒与细胞受体结合的结构,在病毒致病性和嗜神经性中发挥重要作用,与病毒毒力直接相关。作者归纳总结国内外RABV糖蛋白结构与功能研究进展,并对糖蛋白中和抗体的检测与评价进行阐述。将为进一步揭示RABV糖蛋白生物学功能奠定基础,为糖蛋白中和抗体的诊断提供理论参考,为控制和消灭狂犬病做出相应贡献。更多还原

【Abstract】 Rabies is a lethal zoonotic infectious disease caused by rabies virus(RABV),which infected the central nervous system.The RABV glycoprotein exists on the surface of the virus particles,it is a major protective antigen which stimulate the body to produce the humoral immunity and cellular immunity;It is the identification of structure of the cell receptors;It plays an important role in the viral pathogenicity and tropism in the nerve,directly related to the virulence of virus.In this review,we summarized research progress of structure and function of RABV glycoprotein,and also reviewed the detection and evaluation of the neutralizing antibody.All these fundamental studies are important for the control and elimination of the RABV,to provide research basis for further revealing the biological function of RABV glycoprotein.更多还原