【摘要】 目的监测和分析扬州地区2011~2015年脑脊液细菌培养病原菌分布和耐药性变迁,为临床合理选用抗菌药物提供最新依据。方法采用法国生物梅里埃公司的VITEK 2Compact全自动微生物仪,对脑脊液标本进行细菌鉴定和药物敏感试验,应用WHONET 5.6软件分析分离病原菌的分布及药敏情况。结果 2011~2015年的2 074例脑脊液细菌培养中共分离出74例细菌(3.57%),其中位于前3位的分别是鲍曼不动杆菌(21/74,28.38%)、肺炎克雷伯菌(13/74,17.57%)和表皮葡萄球菌(12/74,16.22%)。其中鲍曼不动杆菌对抗菌药物的耐药率极其严重,呈多耐药或泛耐药现象。结论定期监测和分析当地患者脑脊液分离病原菌种类及其耐药性变迁,对指导临床合理使用抗菌药物具有重要意义。更多还原

【Abstract】 Objective To monitor and analyze the distribution of pathogenic bacteria from CSF and its drug resistance change in Yangzhou area during 2011-2015,so as to provide the latest evidence for clinical rational use of antibacterial drugs.Methods The VITEK 2automatic microbiological instrument was applied to identify bacteria and conduct the drug susceptibility test.The distribution and drug susceptibility situation of isolated pathogenic bacteria were analyzed by using the WHONET 5.6software.Results In 2074 CSF bacterial culture from 2011 to 2015,74strains(3.57%)of pathogenic bacteria were isolated,in which the top three were Acinetobacter baumanni(21/74,28.38%),Klebsiella pneumonia(13/74,17.57%)and Staphylococcus epidermis(12/74,16.22%).The resistance rate of acinetobacter baumanni toantibacterial drugs was extremely serious,showing muti-drug or pandrug resistant phenomena.Conclusion Regular monitoring and analyzing the species and change of drug resistance in pathogenic bacteria isolated from CSF have an important significance to guide clinic to rationally use antibacterial drugs.更多还原