【摘要】 目的探讨还原型谷胱甘肽(GSH)联合早期护理干预对新生儿黄疸的治疗效果及对脂质过氧化指标血清丙二醛(MDA)、超氧化物歧化酶(SOD)和氧化型谷胱甘肽(GSH-PX)水平的影响。方法选取新生儿黄疸患儿68例,随机分为观察组(34例)和常规组(34)例。另选取同时期出生的健康足月新生儿20例为健康对照组。观察组在常规组基础上加用GSH治疗及早期护理干预。检测治疗前后血清总胆红素(TBIL)、直接胆红素(DBIL)、MDA、SOD、GSH-Px水平。结果观察组的治疗总有效率为91.2%,明显高于常规组(73.5%)(P<0.05);治疗后,两组患儿血清TBIL、DBIL水平均较治疗前明显下降(均P<0.01),且观察组治疗后TBIL、DBIL水平明显低于常规组(均P<0.01)。治疗前,两组患儿血清MDA水平明显高于健康对照组(均P<0.01),两组SOD、GSH-Px水平明显低于健康对照组(均P<0.01);治疗后,两组患儿血清MDA水平明显下降(P<0.01或0.05),而血清SOD、GSH-Px则明显升高(P<0.01或0.05);与常规组比较,观察组血清MDA水平下降更明显(P<0.05),GSH-Px水平明显增高(P<0.05)。结论 GSH联合早期护理干预对新生儿黄疸具有较好的临床疗效,且能有效降低患儿血清TBIL、DBIL、MDA水平,提高SOD、GSH-Px水平,具有积极的临床意义。更多还原

【Abstract】 Objective To explore the efficacy of glutathione(GSH)combined with early nursing intervention for treating neonatal jaundice,and to investigate its influence on serum malondialdehyde(MDA),superoxides dismutase(SOD)and glutathione-Px(GSH-Px)levels.Methods Sixty-eight cases of neonatal jaundice were chosen and randomly divided into the observation group(n=34)and conventional group(n=34).Contemporaneous 20 full term healthy neonates were selected as the healthy control group.The observation group was added with GSH and early nursing intervention on the basis of the conventional group.Serum total bilirubin(TBIL),direct bilirubin(DBIL),MDA,SOD and GSH-Px levels were detected before and after treatment.Results The total effective rate in the observation group was 91.2%,which was significantly higher than 73.5%in the conventional group(P<0.05);compared with before treatment,serum TBIL and DBIL levels after treatment in the two group were significantly decreased(P<0.01),moreover the levels of TBIL and DBIL after treatment in the observation group were significantly lower than those in the conventional group(P<0.01).The serum MDA level before treatment in both groups were significantly higher than that in the healthy control group(P<0.01),while serum SOD and GSH-Px levels in the two groups were significantly lower than those in the healthy control group(P<0.01);after treatment,serum MDA level in both groups were significantly decreased(P<0.01 or P<0.05),while serum SOD and GSH-Px levels in the two group were significantly increased(P<0.01 or 0.05);compared with the conventional group,decrease of serum MDA level in the observation group was more significant(P<0.05)and serum GSH-Px level was markedly increased(P<0.05).Conclusion GSH combined with early nursing intervention has better effect in the treatment of neotatal jaundice and effectively reduces the levels of serum TBIL,DBIL and MDA,and increases the levels of SOD and GSH-Px,which has positive clinical significance.更多还原